ID RNF44_MOUSE Reviewed; 407 AA.
AC Q3UHJ8; Q3TAC8; Q3TVH9; Q6ZPX8; Q8VD22;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 124.
DE RecName: Full=RING finger protein 44;
GN Name=Rnf44; Synonyms=Kiaa1100;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Osteoclast, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3UHJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UHJ8-2; Sequence=VSP_022550, VSP_022551;
CC Name=3;
CC IsoId=Q3UHJ8-3; Sequence=VSP_022550;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17630.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH35548.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC98100.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK129290; BAC98100.1; ALT_FRAME; mRNA.
DR EMBL; AK147349; BAE27859.1; -; mRNA.
DR EMBL; AK160090; BAE35621.1; -; mRNA.
DR EMBL; AK160115; BAE35639.1; -; mRNA.
DR EMBL; AK171943; BAE42740.1; -; mRNA.
DR EMBL; BC017630; AAH17630.1; ALT_INIT; mRNA.
DR EMBL; BC035548; AAH35548.1; ALT_INIT; mRNA.
DR CCDS; CCDS49266.1; -. [Q3UHJ8-2]
DR CCDS; CCDS49267.1; -. [Q3UHJ8-3]
DR RefSeq; NP_001139497.1; NM_001146025.1.
DR RefSeq; NP_001139498.1; NM_001146026.1. [Q3UHJ8-1]
DR RefSeq; NP_001139499.1; NM_001146027.1. [Q3UHJ8-3]
DR RefSeq; NP_598825.2; NM_134064.2. [Q3UHJ8-2]
DR RefSeq; XP_011242751.1; XM_011244449.1. [Q3UHJ8-3]
DR RefSeq; XP_011242752.1; XM_011244450.1. [Q3UHJ8-3]
DR RefSeq; XP_011242753.1; XM_011244451.1. [Q3UHJ8-2]
DR RefSeq; XP_017170825.1; XM_017315336.1. [Q3UHJ8-3]
DR AlphaFoldDB; Q3UHJ8; -.
DR SMR; Q3UHJ8; -.
DR STRING; 10090.ENSMUSP00000118474; -.
DR iPTMnet; Q3UHJ8; -.
DR PhosphoSitePlus; Q3UHJ8; -.
DR PaxDb; 10090-ENSMUSP00000118474; -.
DR DNASU; 105239; -.
DR Ensembl; ENSMUST00000037422.16; ENSMUSP00000043974.10; ENSMUSG00000034928.17. [Q3UHJ8-2]
DR Ensembl; ENSMUST00000128257.8; ENSMUSP00000116850.2; ENSMUSG00000034928.17. [Q3UHJ8-2]
DR Ensembl; ENSMUST00000134862.8; ENSMUSP00000114259.2; ENSMUSG00000034928.17. [Q3UHJ8-3]
DR Ensembl; ENSMUST00000150806.8; ENSMUSP00000123198.2; ENSMUSG00000034928.17. [Q3UHJ8-3]
DR Ensembl; ENSMUST00000177950.8; ENSMUSP00000136732.2; ENSMUSG00000034928.17. [Q3UHJ8-2]
DR GeneID; 105239; -.
DR KEGG; mmu:105239; -.
DR UCSC; uc007qot.2; mouse. [Q3UHJ8-2]
DR UCSC; uc007qou.2; mouse. [Q3UHJ8-1]
DR AGR; MGI:2145310; -.
DR CTD; 22838; -.
DR MGI; MGI:2145310; Rnf44.
DR VEuPathDB; HostDB:ENSMUSG00000034928; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000158553; -.
DR HOGENOM; CLU_024578_0_0_1; -.
DR InParanoid; Q3UHJ8; -.
DR OrthoDB; 5474929at2759; -.
DR PhylomeDB; Q3UHJ8; -.
DR BioGRID-ORCS; 105239; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Rnf44; mouse.
DR PRO; PR:Q3UHJ8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UHJ8; Protein.
DR Bgee; ENSMUSG00000034928; Expressed in undifferentiated genital tubercle and 259 other cell types or tissues.
DR ExpressionAtlas; Q3UHJ8; baseline and differential.
DR Genevisible; Q3UHJ8; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16680; RING-H2_RNF44; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46171; GH10160P; 1.
DR PANTHER; PTHR46171:SF2; RING FINGER PROTEIN 44; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..407
FT /note="RING finger protein 44"
FT /id="PRO_0000273414"
FT ZN_FING 355..396
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 26..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022550"
FT VAR_SEQ 131
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022551"
SQ SEQUENCE 407 AA; 45497 MW; 0F161D01F3E72CA6 CRC64;
MRPWTLAVTK WPPSAPVGHW RVSTRLSSSP GQLWGRPSNL SVEEHRASAP AGRSPRMLHP
ATQQSPFMVD LHEQVHQGPV PLSYTVTTVT TQGFPLPTSQ HIPGCSAQQL PACSVMFSGQ
HYPLCCLPPP QLIQACTMQQ LPGPYHTYPH LISSDHYILH PPPPAPPPQP THMAPLGQFV
SLQTQHPRMP LQRLDNEMDL RGDQHPLGSF TYSTSATGPA LSPSVPLHYL PHDPLHQELS
FGVPYSHMMP RRLSTQRYRL QQPLPPPPPP PPPSYYPSFL PYFLSMLPMS PTTVGPTISL
DLDVDDVEME NYEALLNLAE RLGDAKPRGL TKADIEQLPS YRFNPDSHQS EQTLCVVCFS
DFEVRQLLRV LPCNHEFHAK CVDKWLKANR TCPICRADAS EVPREAE
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