GenomeNet

Database: UniProt
Entry: Q3UTQ7
LinkDB: Q3UTQ7
Original site: Q3UTQ7 
ID   PRD10_MOUSE             Reviewed;        1184 AA.
AC   Q3UTQ7; Q6P397;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   10-APR-2019, entry version 98.
DE   RecName: Full=PR domain zinc finger protein 10;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 10;
DE   AltName: Full=Tristanin;
GN   Name=Prdm10; Synonyms=Gm1112, Tris;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=12175877; DOI=10.1016/S0736-5748(02)00055-2;
RA   Siegel D.A., Huang M.K., Becker S.F.;
RT   "Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
RT   development.";
RL   Int. J. Dev. Neurosci. 20:373-389(2002).
RN   [5]
RP   ERRATUM.
RA   Siegel D.A., Huang M.K., Becker S.F.;
RL   Int. J. Dev. Neurosci. 21:169-170(2003).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-422, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA   Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA   Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, and Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12175877}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3UTQ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3UTQ7-2; Sequence=VSP_036382, VSP_036383;
CC   -!- TISSUE SPECIFICITY: Present in brain, liver, kidney, spleen and
CC       thymus (at protein level). {ECO:0000269|PubMed:12175877}.
CC   -!- DOMAIN: The SET domain is degenerated, suggesting that it has lost
CC       methyltransferase activity.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AK139221; BAE23923.1; -; mRNA.
DR   EMBL; AC167244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC064128; AAH64128.1; -; mRNA.
DR   UniGene; Mm.335039; -.
DR   ProteinModelPortal; Q3UTQ7; -.
DR   SMR; Q3UTQ7; -.
DR   STRING; 10090.ENSMUSP00000074104; -.
DR   iPTMnet; Q3UTQ7; -.
DR   PhosphoSitePlus; Q3UTQ7; -.
DR   EPD; Q3UTQ7; -.
DR   PeptideAtlas; Q3UTQ7; -.
DR   PRIDE; Q3UTQ7; -.
DR   Ensembl; ENSMUST00000117389; ENSMUSP00000112588; ENSMUSG00000042496. [Q3UTQ7-2]
DR   UCSC; uc009oro.1; mouse. [Q3UTQ7-2]
DR   MGI; MGI:2682952; Prdm10.
DR   GeneTree; ENSGT00940000158740; -.
DR   HOVERGEN; HBG053664; -.
DR   InParanoid; Q3UTQ7; -.
DR   PhylomeDB; Q3UTQ7; -.
DR   PRO; PR:Q3UTQ7; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; ENSMUSG00000042496; Expressed in 138 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; Q3UTQ7; baseline and differential.
DR   Genevisible; Q3UTQ7; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR022755; Znf_C2H2_jaz.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   Pfam; PF12171; zf-C2H2_jaz; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond;
KW   Metal-binding; Methyltransferase; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1184       PR domain zinc finger protein 10.
FT                                /FTId=PRO_0000363963.
FT   DOMAIN      202    320       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     349    371       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     520    542       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     550    572       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     578    600       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     606    629       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     634    656       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     662    685       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     717    740       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     850    873       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    126    136       Poly-Glu.
FT   COMPBIAS    139    144       Poly-Glu.
FT   COMPBIAS    882    932       Thr-rich.
FT   COMPBIAS    934   1056       Gln-rich.
FT   COMPBIAS   1168   1171       Poly-Thr.
FT   MOD_RES     418    418       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9NQV6}.
FT   MOD_RES     422    422       Phosphothreonine.
FT                                {ECO:0000244|PubMed:17525332}.
FT   CROSSLNK    374    374       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV6}.
FT   VAR_SEQ     318    341       WYAASYAEFVNQKIHDISEEERKV -> QNWIHSCLPARVM
FT                                IRALSYKRILP (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_036382.
FT   VAR_SEQ     342   1184       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_036383.
FT   CONFLICT    227    227       F -> S (in Ref. 1; BAE23923).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1184 AA;  133746 MW;  99563C0C4184C15D CRC64;
     MDPKDESAHV WPTSADHEQS TAQVHFVPDA GTVAQIVYTD DQVRPPQQVV YTADGASYTS
     VDGPEHTLVY IHPVEAAQTL FTDPAQVAYV QQDATAQQVL PSIESVHGSD PLATLQNPIA
     RLDAKEEEEE EEDEDEDTEE EEEEDAEDTD VDDWQPDPPR PFDPHDLWCE ECNNAHSSVC
     PKHGPLHPIP NRPVLTRARA SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL
     KDCYIHLKVS LDKGDRKDRD LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH
     VYYTTIKNVE PKQELKVWYA ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS
     SEQLQQHLNS HDEKLDVFTR TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD
     GTQDLLHFPT KEQFDEAEPA TLNGLDQPEQ ASIPIPQLPQ ETPPSLEQEP ETHTLHLQPQ
     QEESLVPTQT TLTADDMRRA KRIRNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR
     FHGREGNCPL TCDLCNKGFI SSASLESHMK LHSDQKTYSC IFCPESFDRL DLLKDHVAIH
     VNDGCFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD KAFCRPDKLR LHMLRHSDRK
     DFLCSTCGKQ FKRKDKLREH MQRMHNPERE AKKADRISRS KTFKPRITST DYDSFTFKCR
     LCMMGFRRRG MLVNHLSKRH PDMKIEEVPE LTLPIIKPNR DYFCQYCDKN EMSYFALSKK
     VALYIAFMVK YLTLQVYKSA SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ
     LTGTIATPPV CCPHCSKQYS SKTKMVQHIR KKHPEYAQLP NTIHTPLTTA VISATPAVLT
     TDSATGETVV TTDLLTQAMT ELSQTLTTDY RTPQGDYQRI QYIPVSQSAS GLQQPQHIQL
     QVVQVAPATS PHQSQQSTVD VGQLHDPQTY TQHAIQVQHI QVTEPAPAAP SASQVAGQPL
     SPSAQQVQQG LSPSHIQGSS STQGQALQQQ QNSSVQHTYL PNAWNSFRGY SAVSAGDTSH
     ESASEIQMMT LPPGQFVITD SGVATPVTSG QVKAVTPGHY VLSESQPELE EKQASALSGA
     VQVQPSAHSD SLDSTGPSQQ QTTQYIITTT TNGNGGSEVH ITKP
//
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