ID Q3UY88_MOUSE Unreviewed; 201 AA.
AC Q3UY88;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 160.
DE SubName: Full=Double homeobox B-like 1 {ECO:0000313|Ensembl:ENSMUSP00000133570.2};
DE SubName: Full=Double homeodomain-related protein {ECO:0000313|EMBL:ABY83065.1};
GN Name=Duxbl1 {ECO:0000313|Ensembl:ENSMUSP00000133570.2,
GN ECO:0000313|MGI:MGI:1916048};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE22324.1};
RN [1] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE22324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22324.1};
RC TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22324.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0000313|EMBL:ABY83065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FVB {ECO:0000313|EMBL:ABY83065.1};
RA Tsai T.-S., Wang S.-H.;
RT "Mus musculus double homeobox-related gene mRNA.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|Ensembl:ENSMUSP00000133570.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133570.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [11] {ECO:0000313|EMBL:ABY83065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FVB {ECO:0000313|EMBL:ABY83065.1};
RX PubMed=20063414; DOI=10.1002/dvdy.22210;
RA Wu S.L., Tsai M.S., Wong S.H., Hsieh-Li H.M., Tsai T.S., Chang W.T.,
RA Huang S.L., Chiu C.C., Wang S.H.;
RT "Characterization of genomic structures and expression profiles of three
RT tandem repeats of a mouse double homeobox gene: Duxbl.";
RL Dev. Dyn. 239:927-940(2010).
RN [12] {ECO:0000313|Ensembl:ENSMUSP00000133570.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133570.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; EU257807; ABY83065.1; -; mRNA.
DR EMBL; AK134879; BAE22324.1; -; mRNA.
DR Antibodypedia; 73101; 314 antibodies from 22 providers.
DR Ensembl; ENSMUST00000172667.8; ENSMUSP00000133570.2; ENSMUSG00000048502.15.
DR AGR; MGI:1916048; -.
DR MGI; MGI:1916048; Duxbl1.
DR VEuPathDB; HostDB:ENSMUSG00000048502; -.
DR VEuPathDB; HostDB:ENSMUSG00000072672; -.
DR VEuPathDB; HostDB:ENSMUSG00000072675; -.
DR GeneTree; ENSGT00940000154537; -.
DR OMA; TVWRNSH; -.
DR ChiTaRS; Duxbl1; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000048502; Expressed in animal zygote and 61 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045580; P:regulation of T cell differentiation; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR46123:SF6; DOUBLE HOMEOBOX B-LIKE; 1.
DR PANTHER; PTHR46123; MIX-TYPE HOMEOBOX GENE 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 2.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 12..72
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 92..140
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 14..73
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 94..141
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 201 AA; 23253 MW; 307C1416E49251E9 CRC64;
MELSCSTGLL EKEARRRRII LTQSQKDTLR VWFEKNPNPD LATRGHLAKE LGISESQIMT
WFQKHRKIRK QAEFACCSEE SQEQEQDKPR VKEARRSRTH FTKFQTDILI EAFEKNRFPG
IVTREKLAQQ TGIPESRIHV RCASLCLWQP TCPYHKPLFS RAVDGQSQAT HGCPCALDTG
CKYLVFPATV WRNSHIRPAE S
//
