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Database: UniProt
Entry: Q40470
LinkDB: Q40470
Original site: Q40470 
ID   IF4A7_TOBAC             Reviewed;         413 AA.
AC   Q40470;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-OCT-2019, entry version 89.
DE   RecName: Full=Eukaryotic initiation factor 4A-7;
DE            Short=eIF-4A-7;
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent RNA helicase eIF4A-7;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
OC   Nicotianoideae; Nicotianeae; Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. SR1;
RX   PubMed=7858215; DOI=10.1007/bf00019489;
RA   Owttrim G.W., Mandel T., Trachsel H., Thomas A.A., Kuhlemeier C.;
RT   "Characterization of the tobacco eIF-4A gene family.";
RL   Plant Mol. Biol. 26:1747-1757(1994).
CC   -!- FUNCTION: ATP-dependent RNA helicase which is a subunit of the
CC       eIF4F complex involved in cap recognition and is required for mRNA
CC       binding to ribosome. In the current model of translation
CC       initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR
CC       of mRNAs which is necessary to allow efficient binding of the
CC       small ribosomal subunit, and subsequent scanning for the initiator
CC       codon (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of
CC       which varies with external and internal environmental conditions.
CC       It is composed of at least EIF4A, EIF4E and EIF4G (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. eIF4A
CC       subfamily. {ECO:0000305}.
DR   EMBL; X79137; CAA55738.1; -; mRNA.
DR   PIR; S52019; S52019.
DR   RefSeq; NP_001312302.1; NM_001325373.1.
DR   SMR; Q40470; -.
DR   PRIDE; Q40470; -.
DR   GeneID; 107783883; -.
DR   KEGG; nta:107783883; -.
DR   KO; K03257; -.
DR   Proteomes; UP000084051; Genome assembly.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN         1    413       Eukaryotic initiation factor 4A-7.
FT                                /FTId=PRO_0000054954.
FT   DOMAIN       71    241       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      252    413       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      84     91       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        40     68       Q motif.
FT   MOTIF       189    192       DEAD box.
SQ   SEQUENCE   413 AA;  46897 MW;  C1FE4FFF99032CE6 CRC64;
     MAGLAPEGSQ FDARQYDAKM TELLGTEQEE FFTSYDEVYD SFDAMGLQEN LLRGIYAYGF
     EKPSAIQQRG IVPFCKGLDV IQQAQSGTGK TATFCSGVLQ QLDYSLVECQ ALVLAPTREL
     AQQIEKVMRA LGDYLGVKVH ACVGGTSVRE DQRILQSGVH VVVGTPGRVF DMLRRQSLRP
     DHIKMFVLDE ADEMLSRGFK DQIYDIFQLL PPKIQVGVFS ATMPPEALEI TRKFMNKPVR
     ILVKRDDVTL EGIKQFYVNV DKEEWKLETL CDLYETLAIT QSVIFVNTRR KVDWLTDKMR
     TRDHTVSATH GDMDQNTRDI IMREFRSGSS RVLITTDLLA RGIDVQQVSL VINYDLPTQP
     ENYLHRIGRS GRFGRKGVAI NFVIKDDERM LSDIQRFYNV VIEELPANVA DLL
//
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