ID   Q469B3_METBF            Unreviewed;       239 AA.
AC   Q469B3;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Peptidase M50 domain-containing protein {ECO:0000259|Pfam:PF02163};
GN   OrderedLocusNames=Mbar_A2620 {ECO:0000313|EMBL:AAZ71529.1};
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ71529.1};
RN   [1] {ECO:0000313|EMBL:AAZ71529.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fusaro {ECO:0000313|EMBL:AAZ71529.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RT   "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP000099; AAZ71529.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q469B3; -.
DR   STRING; 269797.Mbar_A2620; -.
DR   PaxDb; 269797-Mbar_A2620; -.
DR   KEGG; mba:Mbar_A2620; -.
DR   eggNOG; arCOG00607; Archaea.
DR   HOGENOM; CLU_080388_0_0_2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd06164; S2P-M50_SpoIVFB_CBS; 1.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR39188; MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B; 1.
DR   PANTHER; PTHR39188:SF3; ZINC METALLOPROTEASE SLR1821-RELATED; 1.
DR   Pfam; PF02163; Peptidase_M50; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        109..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..128
FT                   /note="Peptidase M50"
FT                   /evidence="ECO:0000259|Pfam:PF02163"
FT   DOMAIN          137..201
FT                   /note="Peptidase M50"
FT                   /evidence="ECO:0000259|Pfam:PF02163"
SQ   SEQUENCE   239 AA;  26335 MW;  5A0A57EFA2392C03 CRC64;
     MQSSFKIGNI MDIPIKLDTS FLLALPISAY FFAINSQPYG FAGVEPIIVK YALSTLSAIF
     LFVSVLLHEL SHSYLAKRYG ANIHSITLLL FGGVASMEIP QKPGQEAKIA FAGPLMSLVI
     GLICLFTYNY VISSNSALSQ NPIYLIVWVI GSMNLVLGIF NLLPAFPMDG GRILRSVFAR
     KMSYVKATHS AASIGKFFAV LMAIYGFYVG DIWFTLIALY IYGSASNEDR FYSELDRSV
//