ID   Q46AF1_METBF            Unreviewed;       283 AA.
AC   Q46AF1;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   SubName: Full=2-oxoacid ferredoxin oxidoreductase, subunit beta {ECO:0000313|EMBL:AAZ71141.1};
GN   OrderedLocusNames=Mbar_A2215 {ECO:0000313|EMBL:AAZ71141.1};
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ71141.1};
RN   [1] {ECO:0000313|EMBL:AAZ71141.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fusaro {ECO:0000313|EMBL:AAZ71141.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RT   "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP000099; AAZ71141.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46AF1; -.
DR   STRING; 269797.Mbar_A2215; -.
DR   PaxDb; 269797-Mbar_A2215; -.
DR   KEGG; mba:Mbar_A2215; -.
DR   eggNOG; arCOG01599; Archaea.
DR   HOGENOM; CLU_048564_0_0_2; -.
DR   OrthoDB; 30755at2157; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd03375; TPP_OGFOR; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR011896; OFOB.
DR   InterPro; IPR032686; PFO_beta_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR02177; PorB_KorB; 1.
DR   PANTHER; PTHR48084:SF4; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB; 1.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   Pfam; PF12367; PFO_beta_C; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          52..194
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   DOMAIN          198..261
FT                   /note="Pyruvate ferredoxin oxidoreductase beta subunit C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12367"
SQ   SEQUENCE   283 AA;  31805 MW;  6D143571DE855042 CRC64;
     MPTSEDYKGQ VPAWCPGCGN FNILSTVKQA LVELGIEPWE VLMVSGIGQS GKLPHYMKCH
     TFNGLHGRTL PVATAAKLAN HSLHVIAVAG DGDCYGEGGN HFLHAIRRNP NITLLVHDNQ
     IYGLTKGQAS PTTAQGTHTK IQPYGVLEEP LNPLALAISQ DCSFVARGFA GDQSYLKELL
     KAAISHKGFS LLDILQPCVT FNKINTFRWY RDRVYKLEEE YDPYNRLKAF ERSLEWGDRI
     PNGIFYKSER ETLEEGIPTI QEEPLVRQKF SIEDVKHEID KFY
//