ID   Q46EA0_METBF            Unreviewed;       918 AA.
AC   Q46EA0;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Sensory transduction histidine kinase {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=Mbar_A0815 {ECO:0000313|EMBL:AAZ69792.1};
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ69792.1};
RN   [1] {ECO:0000313|EMBL:AAZ69792.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fusaro {ECO:0000313|EMBL:AAZ69792.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RT   "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000099; AAZ69792.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46EA0; -.
DR   STRING; 269797.Mbar_A0815; -.
DR   PaxDb; 269797-Mbar_A0815; -.
DR   KEGG; mba:Mbar_A0815; -.
DR   eggNOG; arCOG02352; Archaea.
DR   eggNOG; arCOG02359; Archaea.
DR   HOGENOM; CLU_334534_0_0_2; -.
DR   OrthoDB; 8127at2157; -.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 2.10.70.100; -; 1.
DR   Gene3D; 3.30.450.40; -; 2.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF13185; GAF_2; 2.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07568; HisKA_2; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00086; PAC; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          490..544
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          595..642
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          644..696
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          704..906
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          532..577
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   918 AA;  104341 MW;  98D26A32D62CFC07 CRC64;
     MTTKHTDGWE PITYQELLDE NKLLVDENRT LKNKIQCLRA YLKQDKEPKY DIDKPDLERR
     QAHLLVKADL EALTRIHELS TKLLGSEGIQ PLLKEIMDAA ISVVNAKMGT LQLLEDDSLH
     IVAHYGHKQP FLDYFTSAEN VASVCGKVMQ RGERIVIEDV ETSSIFAGTP SLTVMREAGV
     RAIQSTPMLS RTGELLGILT TQWNFPYSPN EHDLWRLDLL ARQAADMIEQ ARSEEALNDS
     KKCLMADLNA MTRLHKIGTL FVRESNLEPV LVEIVDAAIA ISDADFGNIQ LLDPESSELK
     IVASRGFPKW WLDFWDSVSV GNGTCGTALG REEKVIVEDI EQSPIFVGTP ALEIQLKAGI
     RAVQSTPIVS RSGRLLGMFS THYKKPHKLQ DHGLQLIDLL AQQAADIIER AQIEEMLRKS
     EERFRVALQG SSVVISSQDR DLRYTWAYNP SPGFKLEDLL GKNDYDIYQL DDAEAFVSIK
     KQVLASGVSQ CDEVVIHRPA SAGGDLFHEM TTEPLRDATG TIVGVICIAV DITERKRAEE
     ALKKANDTLE EKIKERTVEL EEAYNSLLEN KMRLSEAQKI AHLGNWDWNL VTDELYWSDE
     IHNIFGLDSL EFDETYDAFL NLVLPEDREY VNNAFKKAFC GKSFEIDFRI ISADREEHIL
     YARGQVIFDE KNTPIRVRGI VQDITERKKT EEALVKLEKV RIKEIHHRIK NNLQVISSLL
     DLQAEKFEDK KVKQAFSESQ NRVFSMSLIH EELYKGGQAE KLNFSAYLEK LADNLLMTYR
     LSRINIRLNM DLEENAFLDM DTAVPLGIIV NELISNSLKH AFTEKKEGEI GIQLRRHEET
     INGIHKSDFC LKVSDNGKGI PEDLKLESVE SLGMQLINTL VNQLDGELKL KRNKGTEFTV
     RFKVIEKTPK YQRQTYSP
//