ID EXPR_DICD3 Reviewed; 250 AA.
AC Q47188; E0SME7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Transcriptional activator protein ExpR;
GN Name=expR; OrderedLocusNames=Dda3937_03218;
OS Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Dickeya.
OX NCBI_TaxID=198628;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=3937;
RX PubMed=9781877; DOI=10.1046/j.1365-2958.1998.01022.x;
RA Nasser W., Bouillant M.L., Salmond G., Reverchon S.;
RT "Characterization of the Erwinia chrysanthemi expI-expR locus directing the
RT synthesis of two N-acyl-homoserine lactone signal molecules.";
RL Mol. Microbiol. 29:1391-1405(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3937;
RX PubMed=21217001; DOI=10.1128/jb.01513-10;
RA Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA Blattner F.R., Keen N.T., Perna N.T.;
RT "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL J. Bacteriol. 193:2076-2077(2011).
CC -!- FUNCTION: Functions as an OHLL responsive transcriptional regulator
CC that acts in virulence (soft rot disease) through the activation of
CC genes for plant tissue macerating enzymes.
CC -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC regulatory protein family. {ECO:0000305}.
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DR EMBL; X96440; CAA65307.1; -; Genomic_DNA.
DR EMBL; CP002038; ADN00586.1; -; Genomic_DNA.
DR RefSeq; WP_013319981.1; NC_014500.1.
DR AlphaFoldDB; Q47188; -.
DR SMR; Q47188; -.
DR STRING; 198628.Dda3937_03218; -.
DR GeneID; 9735887; -.
DR KEGG; ddd:Dda3937_03218; -.
DR PATRIC; fig|198628.6.peg.4339; -.
DR eggNOG; COG2771; Bacteria.
DR HOGENOM; CLU_072786_5_0_6; -.
DR OrthoDB; 9774661at2; -.
DR Proteomes; UP000006859; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.30.450.80; Transcription factor LuxR-like, autoinducer-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR44688; -; 1.
DR PANTHER; PTHR44688:SF28; CSGBAC OPERON TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF03472; Autoind_bind; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF75516; Pheromone-binding domain of LuxR-like quorum-sensing transcription factors; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Quorum sensing; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..250
FT /note="Transcriptional activator protein ExpR"
FT /id="PRO_0000184153"
FT DOMAIN 173..238
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 197..216
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT CONFLICT 116
FT /note="D -> S (in Ref. 1; CAA65307)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 28716 MW; 48B86236007352FD CRC64;
MSISFSNVDF INSTIQSYLN RKLKSYGDPK YAYLIMNKKK PTDVVIISNY PTEWVDIYRN
NNYQHIDPVI LTAINKISPF SWDDDLVISS KLKFSRIFNL SKDYDIVNGY TFVLHDPGNN
LAALSFMIEE HRSEELEEII QNNKDKLQML LISAHEKLTS LYREMSRNRN NSKSQEADLF
SQRENEILHW ASMGKTYQEI ALILGITTST VKFHIGNVVK KLGVLNAKHA IRLGVEMNLI
KPVGPAKARS
//
