ID Q47L13_THEFY Unreviewed; 227 AA.
AC Q47L13;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN OrderedLocusNames=Tfu_2826 {ECO:0000313|EMBL:AAZ56859.1};
OS Thermobifida fusca (strain YX).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Thermobifida.
OX NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ56859.1};
RN [1] {ECO:0000313|EMBL:AAZ56859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YX {ECO:0000313|EMBL:AAZ56859.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of Thermobifida fusca YX.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; CP000088; AAZ56859.1; -; Genomic_DNA.
DR AlphaFoldDB; Q47L13; -.
DR STRING; 269800.Tfu_2826; -.
DR KEGG; tfu:Tfu_2826; -.
DR eggNOG; COG0693; Bacteria.
DR HOGENOM; CLU_070319_1_1_11; -.
DR OrthoDB; 9792284at2; -.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AAZ56859.1};
KW Protease {ECO:0000313|EMBL:AAZ56859.1};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 31..222
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 227 AA; 24179 MW; 3D36B9A293BA92F3 CRC64;
MPNLPKRVLL ALTSHGSLGD TGKPTGYYVP EAAHPWEVFR KAGYEVSFVS VKGGQPPATG
YNAEDEVQRE FLEDPEVKKA LADTPTADSL NPADYAAVYF VGGHGTMWDF PDAADLAALA
RDIYEAGGVV AAVCHGPAGL VNLKLSDGRY LVEGKEFASF TNEEEDAVNL SGVVPFLLQS
KLEERGGIHV KKPKFESCVV VSERLVTGQN PASASGVAEE TVKLLAD
//
