ID Q47PB8_THEFY Unreviewed; 700 AA.
AC Q47PB8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN OrderedLocusNames=Tfu_1666 {ECO:0000313|EMBL:AAZ55701.1};
OS Thermobifida fusca (strain YX).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Thermobifida.
OX NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ55701.1};
RN [1] {ECO:0000313|EMBL:AAZ55701.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YX {ECO:0000313|EMBL:AAZ55701.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of Thermobifida fusca YX.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
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DR EMBL; CP000088; AAZ55701.1; -; Genomic_DNA.
DR AlphaFoldDB; Q47PB8; -.
DR STRING; 269800.Tfu_1666; -.
DR MEROPS; C26.955; -.
DR KEGG; tfu:Tfu_1666; -.
DR eggNOG; COG0147; Bacteria.
DR eggNOG; COG0512; Bacteria.
DR HOGENOM; CLU_006493_0_1_11; -.
DR OrthoDB; 3518032at2; -.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AAZ55701.1};
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605,
KW ECO:0000313|EMBL:AAZ55701.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAZ55701.1}.
FT DOMAIN 4..187
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 256..393
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 437..690
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 198..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 82
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 700 AA; 75582 MW; 056F756D4C2C1B83 CRC64;
MRVLLVDNHD SYTYNLVHLL ARTLGEEPLV VTNDDPRWKC LDPADFDAAV ISPGPGRPQR
ASDVGHTRRV LDEPHLPILG VCLGHQAIAH HAGAAVVSAP RPRHGHLSRV RHDNSALFAG
IPQDFTAVRY HSLCVASPLP EDVEATAWAE DGVVMALRHR VLPRWGVQFH PESVASDHGP
TLVANFVRLA RAHRRVVAGR PGATAQQSGS PRPALHTTPV RPGQQGVPPT GAAPRALHEV
RKTLRFRVMP RAVDTEAAFL TCYAGRDYAF WLDSSLTGGT ARFSFLGGLD SPQSEVLTYR
VGDGTVAVRS ADGTTHTEPG TIFDALATRT ASAPYGRPDL PFDFLGGYVG YFGYELKADC
GGTAVHRAAT PDAVWLRCDR FIAVDHAADR TYLVAVDGDE AWLDAMARSL SGLRSPSALQ
QTGRGVDPTP FLERSPDDYV ADVKRCLEEL AAGESYEICL TTRARLPAPG DGTAFYLRLR
RANPAPYAAL LHAGETAVYS ASPERFLRVT PDGWVESRPI KGTAPRHDDP VRDARARDAL
RGDPKTRAEN LMIVDLLRND LGRVCEIGSV EVPAFLYTES YATVHQLIST IRGRLRADRS
AVDAVAACFP PGSMTGAPKK RTMEIVDRLE TSARGVYSGA LGYLSFSGTA DLSVVIRTAV
CHDGQVTVGA GGAVVLESVP EREYAEMLLK AAVPLRALEA
//
