ID Q488L4_COLP3 Unreviewed; 789 AA.
AC Q488L4;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Cold-active alkaline serine protease {ECO:0000313|EMBL:AAZ24841.1};
DE EC=3.4.21.62 {ECO:0000313|EMBL:AAZ24841.1};
GN OrderedLocusNames=CPS_0751 {ECO:0000313|EMBL:AAZ24841.1};
OS Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS psychroerythus).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Colwellia.
OX NCBI_TaxID=167879 {ECO:0000313|EMBL:AAZ24841.1, ECO:0000313|Proteomes:UP000000547};
RN [1] {ECO:0000313|EMBL:AAZ24841.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=34H {ECO:0000313|EMBL:AAZ24841.1};
RX PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT "The psychrophilic lifestyle as revealed by the genome sequence of
RT Colwellia psychrerythraea 34H through genomic and proteomic analyses.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CP000083; AAZ24841.1; -; Genomic_DNA.
DR RefSeq; WP_011041600.1; NC_003910.7.
DR AlphaFoldDB; Q488L4; -.
DR SMR; Q488L4; -.
DR STRING; 167879.CPS_0751; -.
DR KEGG; cps:CPS_0751; -.
DR HOGENOM; CLU_011263_15_3_6; -.
DR Proteomes; UP000000547; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04817; PA_VapT_like; 1.
DR CDD; cd07477; Peptidases_S8_Subtilisin_subset; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007280; Peptidase_C_arc/bac.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034202; Subtilisin_Carlsberg-like.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF04151; PPC; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..789
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004234383"
FT DOMAIN 163..554
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 399..481
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 599..663
FT /note="Peptidase C-terminal archaeal/bacterial"
FT /evidence="ECO:0000259|Pfam:PF04151"
FT DOMAIN 706..774
FT /note="Peptidase C-terminal archaeal/bacterial"
FT /evidence="ECO:0000259|Pfam:PF04151"
FT ACT_SITE 170
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 203
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 506
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 789 AA; 81945 MW; 45F282F76EECF4CC CRC64;
MKNNRKLVLS TIALSVLAVT SAASNATPQA QLNKAEKMTT AQSSTLSFAQ WRAQQKLERT
DYTDRLIITF KDKKQGKSVP PGLAKKIGLN LKHVKILKNN SHVIALDEMH AVKDVEKFIE
KLRKHPSVVS IEPDYQRFLM AQNQPWGISK TQSDQLTDND AANMTVCIID SGYQRNNPDL
NANNAAGTNN SGTGNWYENG GSHGTHVAGT IAGVNNSEGV VGILPSTNVN LHIVKVFNEA
GWGYSGDLSD AVDTCVNNGA KVINMSLGGS GSSNTEKNAL QAAADTGVLL IAASGNDGNA
TLSYPASYDA VMAVGALDSN NQHAEFSQYT SQVEVSAPGE AILSTVAGDG RLGFITVGST
TYGNDSVVPQ THYIQSAGNF VVSNVDGAAN GVLSSCTISG SSYSCSNVNG NICLAERNDN
QKGSNYPEIN PAKACADAGA SAVIVYSDST RPGLQNPFLV DANTDVTVPT VSVSRALGQQ
LMTQLGSNAS LTVNSSQDYA YYNGTSMATP HVTGVAALVW SNNPNCTADD VRSALKNTAV
DLDAAGRDDK TGFGLVQAKA ASDALAASCG GGTTPPPPTG NTLTNGVAKT NLGSSTELSF
TMEVPAGATE LNFAMAGGTG DADLYVKFGS APTTSSYDCR PYKGGNTESC PIASVQAGTY
HVKMIAYSAF TGVSLTGSFT EPTTGGGATG GSASVTDISV ARQAWTYYTI DVPAGMATLD
FAMSGGTGDA DMYIRRGSQP TSSTYDCRPY KSGNTEACAF TNPAADTWHI GVYGYSAASG
VSLDVTYNP
//
