ID Q48AA7_COLP3 Unreviewed; 537 AA.
AC Q48AA7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Putative tryptophan halogenase {ECO:0000313|EMBL:AAZ28359.1};
GN OrderedLocusNames=CPS_0239 {ECO:0000313|EMBL:AAZ28359.1};
OS Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS psychroerythus).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Colwellia.
OX NCBI_TaxID=167879 {ECO:0000313|EMBL:AAZ28359.1, ECO:0000313|Proteomes:UP000000547};
RN [1] {ECO:0000313|EMBL:AAZ28359.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=34H {ECO:0000313|EMBL:AAZ28359.1};
RX PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT "The psychrophilic lifestyle as revealed by the genome sequence of
RT Colwellia psychrerythraea 34H through genomic and proteomic analyses.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
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DR EMBL; CP000083; AAZ28359.1; -; Genomic_DNA.
DR AlphaFoldDB; Q48AA7; -.
DR STRING; 167879.CPS_0239; -.
DR KEGG; cps:CPS_0239; -.
DR HOGENOM; CLU_022247_0_0_6; -.
DR Proteomes; UP000000547; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 85
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 16..19
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 85
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 199
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 363
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 372
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 537 AA; 60063 MW; 23502861CA684D32 CRC64;
MHIMNKLTKT VVIVGGGIAG WLTAGRLAAK HKSNTEQGLN VILIESANIP AVGVGEGTWP
TMRSTLRALG ISESDFIREC EASFKQGAKF AKWFDGTEDD FYYHPLVLPQ GFGKTDLAAH
WLAKQTQTKQ KNSHVNSFSN EVCYQEAICE QGLAPKTIRH AEFSDVANYA YHLDSAKFAV
FLQKHCQEKL GVTHIVDDVT GVNCDVNRAD KDIIDETIDK GDILSVSTQN HGDIAGELFV
DCTGFSSLLL GKHYQVPFKK CDDILFIDTA LAVQVPYDSK DSPIASHTIS TGQKAGWIWD
IGLQHRRGVG YVYSSKHSTE AEARAVLAEY VGDKFSSLNV RKIPIVSGHR EKFWQNNCVA
VGLSAGFLEP LEASALVMVE LAAQMISEQL PASREVMDVV AKRFNETALY RWDRIIDFLK
LHYILSERTE PFWTDNRESA TIPQSLQDLM TEWKYRSPAD HDFTSNNEVF PAASYQYVLY
GMGFKSDYCH TPYAFDDCDF ADGQFKQNKV LIDKALSSLP SNRELLDKIK SYGFSRI
//
