ID LTAA_STAS1 Reviewed; 398 AA.
AC Q49WE5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Proton-coupled antiporter flippase LtaA {ECO:0000250|UniProtKB:Q2FZP8};
DE AltName: Full=Lipoteichoic acid protein A {ECO:0000250|UniProtKB:Q2FZP8};
GN Name=ltaA; OrderedLocusNames=SSP1769;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Proton-coupled antiporter flippase that catalyzes the
CC translocation, from the inner to the outer leaflet of the cell
CC membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors
CC lipoteichoic acids (LTA) to the cell membrane.
CC {ECO:0000250|UniProtKB:Q2FZP8}.
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000250|UniProtKB:Q2FZP8}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2FZP8};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q2FZP8}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. LtaA family.
CC {ECO:0000305}.
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DR EMBL; AP008934; BAE18914.1; -; Genomic_DNA.
DR RefSeq; WP_011303474.1; NZ_MTGA01000039.1.
DR AlphaFoldDB; Q49WE5; -.
DR SMR; Q49WE5; -.
DR KEGG; ssp:SSP1769; -.
DR PATRIC; fig|342451.11.peg.1765; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_054518_0_0_9; -.
DR UniPathway; UPA00556; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd17325; MFS_MdtG_SLC18_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23519; AUTOPHAGY-RELATED PROTEIN 22; 1.
DR PANTHER; PTHR23519:SF1; AUTOPHAGY-RELATED PROTEIN 22; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Lipid transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Virulence.
FT CHAIN 1..398
FT /note="Proton-coupled antiporter flippase LtaA"
FT /id="PRO_0000287164"
FT TRANSMEM 15..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..389
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 398 AA; 44327 MW; C3DA7407FF29BA52 CRC64;
MQSSSLNNYN SNKNFIIMLI ILFLMEFARG MYILSYLALL PTATSIAVGI TSIAISIHFI
ADATTNFVIG FLLKRLGTKL VLTLGFLLAF ASLFLVIWFP TSPFVLIASA ILLGIAVSPI
WVIMLASVDE NNRGKQMGYV YFSWLLGLLV GMVGMNVIFK FHPTQFAFLM SLVVLIAWIL
YYFVKVRLTN YNTRPVKQQL GQIVDVTKRH MILFPGILLQ GASITALVPI LPTYATKVVG
VSTLEYTMAI VFGGIGCAIS MLFLSKIIDK HGTLFMYWVI FGGFVLYTLM IFALSLITNI
TIVWVLAVFI GLMYGILLPA WNTFMASHIH SDEQEETWGV FNSVQGFGSM IGPLVGGLIT
EFTKSVNNTF YFSALVFLFL AIFYGIYFVK VNNKTKTS
//
