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Database: UniProt
Entry: Q49ZM5
LinkDB: Q49ZM5
Original site: Q49ZM5 
ID   Y606_STAS1              Reviewed;         318 AA.
AC   Q49ZM5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JAN-2019, entry version 92.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase SSP0606;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=SSP0606;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AP008934; BAE17751.1; -; Genomic_DNA.
DR   RefSeq; WP_002482556.1; NZ_MTGA01000036.1.
DR   ProteinModelPortal; Q49ZM5; -.
DR   SMR; Q49ZM5; -.
DR   STRING; 342451.SSP0606; -.
DR   EnsemblBacteria; BAE17751; BAE17751; SSP0606.
DR   GeneID; 3616100; -.
DR   KEGG; ssp:SSP0606; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   OMA; KWIAHNG; -.
DR   OrthoDB; 1638924at2; -.
DR   BioCyc; SSAP342451:G1G2H-586-MONOMER; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    318       Putative 2-hydroxyacid dehydrogenase
FT                                SSP0606.
FT                                /FTId=PRO_0000312192.
FT   NP_BIND     156    157       NAD. {ECO:0000250}.
FT   NP_BIND     235    237       NAD. {ECO:0000250}.
FT   NP_BIND     284    287       NAD. {ECO:0000250}.
FT   ACT_SITE    237    237       {ECO:0000250}.
FT   ACT_SITE    266    266       {ECO:0000250}.
FT   ACT_SITE    284    284       Proton donor. {ECO:0000250}.
FT   BINDING     261    261       NAD. {ECO:0000250}.
SQ   SEQUENCE   318 AA;  34974 MW;  938DCFD425F8DD03 CRC64;
     MVKVYIAGPI PEVGLNLLKD QGFEVDMYEG TGIIDKETLK QGVKDADALI SLLSTSVDKE
     VIDAANNLKI ITNYGAGFNN VDIDYARQQN IDVTNTPKAS TNSTAELTFA LVLAVARRIP
     EGDKLCRTTG FDGWAPLFFR GREVSGKTIG IIGLGEIGSA VARRAKAFDM NILYTGPHQK
     VDKEREIGAK YVDLETLLKN ADFVTINAAY NPSLHHQIDK AQFEMMKPTS YLINASRGPI
     VHEKALVQAL KDKEIEGAAL DVFEFEPEIN DELKTLDNVV ITPHIGNATF ESRDMMSKIV
     ANDTISKLNN DQPKFIVN
//
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