ID Q4CNM8_TRYCC Unreviewed; 515 AA.
AC Q4CNM8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN81880.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053509927.10 {ECO:0000313|EMBL:EAN81880.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN81880.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN81880.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN81880.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN81880.1}.
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DR EMBL; AAHK01002895; EAN81880.1; -; Genomic_DNA.
DR RefSeq; XP_803326.1; XM_798233.1.
DR AlphaFoldDB; Q4CNM8; -.
DR SMR; Q4CNM8; -.
DR STRING; 353153.Q4CNM8; -.
DR PaxDb; 353153-Q4CNM8; -.
DR EnsemblProtists; EAN81880; EAN81880; Tc00.1047053509927.10.
DR GeneID; 3532968; -.
DR KEGG; tcr:509927.10; -.
DR InParanoid; Q4CNM8; -.
DR OrthoDB; 138574at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 105..432
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 515
FT /evidence="ECO:0000313|EMBL:EAN81880.1"
SQ SEQUENCE 515 AA; 54827 MW; 7CB3E76AA7FB8B2A CRC64;
MLSRVAAVKA PRTHNRRGVT GSSGRRREGG ESEQQRPNMS RRVSTSAVLL LLLVVMMCCG
VREAASGDGS SGEGKAVDPF QGTKPAPYKW QEMTGSEAAA GSLRVPSLAE VAGGVFAVAE
AQCSERDGAC GHAAIASTHI ETGGGGSKAI SAMDAGVSLV ELVDAASGTT RAQEKMQPTT
IVSGDSIYMA LGDYEKETSG GRAADADGWR LLLTRGTLTE DGGQKKIMWG DIRAVDPVAI
GLTQFLKRVI GGGGSGVVTK NGYLVLPMQA VEKDGRSVVL SMRFNMRIEA WELSSGTTGS
NCKEPSIANL EGNLILITSC AAGYYEVFRS IDSGIRWEMS GRPISRVWGN SYDRKGYGVR
CGLTTVTIEG REVLLVTTPV YLEEKKGRGR LYLWVTDGAR VHDAGPISDA ADDAAASSLL
YSSGGDLISL YENKSEGSYG LVAVHVTTEL ERIKTVVKRW QELDEALRTC RPTATIDPVR
RGMCIRPILT DGLVGYLSGL STGSEWMDEY LCVNA
//
