ID Q4CQ34_TRYCC Unreviewed; 785 AA.
AC Q4CQ34;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=Tc00.1047053507297.20 {ECO:0000313|EMBL:EAN82386.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN82386.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN82386.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN82386.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN82386.1}.
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DR EMBL; AAHK01002533; EAN82386.1; -; Genomic_DNA.
DR RefSeq; XP_804237.1; XM_799144.1.
DR AlphaFoldDB; Q4CQ34; -.
DR SMR; Q4CQ34; -.
DR STRING; 353153.Q4CQ34; -.
DR PaxDb; 353153-Q4CQ34; -.
DR EnsemblProtists; EAN82386; EAN82386; Tc00.1047053507297.20.
DR GeneID; 3533612; -.
DR KEGG; tcr:507297.20; -.
DR eggNOG; KOG2007; Eukaryota.
DR InParanoid; Q4CQ34; -.
DR OMA; EAYWSTP; -.
DR OrthoDB; 2140072at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 1.20.120.1910; Cysteine-tRNA ligase, C-terminal anti-codon recognition domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 54..480
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
FT COILED 666..693
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 785 AA; 89245 MW; 8C2221A90D2BB693 CRC64;
MSTSRHQPQV VGGLKVTEPV RRPRHPPWYP PVQNDAKGLR VLNSLTESVE PFAPREGRLV
RWYACGPTVY ELSHMGHARA YLTFDILRRI MEDYFGYQVV YQMNITDIDD KIIKRARISA
LLKRFREDFL QGRDMARLVA FTAEAETAAV EALELARIKF SEPLPDTTPS RIKAEREEKQ
MELALKESQL QKTRERIASA TASGNFDELF NAASGINGDL LDEREGQYVT DQSIFEDHAR
LYERLFFEDM RRLGVRDPDV VSRVTEYVPQ VVDFIQKIMD NGFAYRGTSS IFFDTAAFLR
AGHDYPKLKP VSERGENDAT EAEMAEGEGA LTVGVAGEKR NANDFALWKF SKPGEPRWPS
PWGAGRPGWH IECSVMASDI LGTNIDVHSG GWDLKFPHHD NECAQSEACH MQHQWINYFL
HCGHLHIKGL KMSKSLKNFI TIRQALDELD VTPRVMRLLF LANHWGKPMN FSDQSIEEAK
ERERVLRAFF GSVDIVLRKD NWGKTQGLND HDRRLQETWL TAENAVHGAL QNNFDTPAAM
DSVMGLVGAT NHYLLSGERP SATLVRKVGR YVTRILQVFG VVEGTDMVGF ATQQGSDDRL
LTVMDALLRF RDGVRDAAKV ENSTETFLPL CDAVRDEWLV PAGIRIEDNP AGPTTWKSDD
VAVLQREVAE RRAQQATERR TRLENQIETK RKLTEKWRQY TCTPIRYFST RDTEEKKYAA
FDEATGLPTR RATGEALGEK EQKKLAKELA RYAKVHEEFV AKGGEGWLAE QEKELASLCQ
ALESL
//
