ID Q4CQ58_TRYCC Unreviewed; 268 AA.
AC Q4CQ58;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 60.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN82410.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053510843.19 {ECO:0000313|EMBL:EAN82410.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN82410.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN82410.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN82410.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN82410.1}.
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DR EMBL; AAHK01002520; EAN82410.1; -; Genomic_DNA.
DR RefSeq; XP_804261.1; XM_799168.1.
DR AlphaFoldDB; Q4CQ58; -.
DR SMR; Q4CQ58; -.
DR PaxDb; 353153-Q4CQ58; -.
DR EnsemblProtists; EAN82410; EAN82410; Tc00.1047053510843.19.
DR GeneID; 3533637; -.
DR KEGG; tcr:510843.19; -.
DR VEuPathDB; TriTrypDB:TcCLB.510843.19; -.
DR InParanoid; Q4CQ58; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR Pfam; PF13859; BNR_3; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..268
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 268
FT /evidence="ECO:0000313|EMBL:EAN82410.1"
SQ SEQUENCE 268 AA; 28413 MW; 7B2E79821350CE8C CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGGRREGR ESEPQRPHMS RRVFASAVLL LLFVTCCGIG
GAVSAGGSNV RGTVDALMGI GWEKLENWED VPDAGGKYGS LRVPSLVEVQ GHVFAIAEAH
CRDGDKCSKF GFTGIASKYL GLSGVSGPTE ISTADASIFG TDLLKKGSEV INTRNGITRP
TTVVIEDSVY VLLGNYSRTR PQVGGTNERG LLLVKGTVIE ENGTKKIRWN ETHVVKPEPK
GYSRSLTELT GGGGSGAVIS DGALVFPM
//
