ID Q4CRF5_TRYCC Unreviewed; 282 AA.
AC Q4CRF5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Elongation factor 1-alpha (EF-1-alpha), putative {ECO:0000313|EMBL:EAN82859.1};
GN ORFNames=Tc00.1047053511369.30 {ECO:0000313|EMBL:EAN82859.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN82859.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN82859.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN82859.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN82859.1}.
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DR EMBL; AAHK01002282; EAN82859.1; -; Genomic_DNA.
DR RefSeq; XP_804710.1; XM_799617.1.
DR AlphaFoldDB; Q4CRF5; -.
DR SMR; Q4CRF5; -.
DR STRING; 353153.Q4CRF5; -.
DR PaxDb; 353153-Q4CRF5; -.
DR EnsemblProtists; EAN82859; EAN82859; Tc00.1047053511369.30.
DR GeneID; 3534247; -.
DR KEGG; tcr:511369.30; -.
DR InParanoid; Q4CRF5; -.
DR OrthoDB; 119577at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR44830; ELONGATION FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR44830:SF1; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EAN82859.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EAN82859.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 81..147
FT /note="Translation elongation factor EFTu-like"
FT /evidence="ECO:0000259|Pfam:PF03144"
FT DOMAIN 155..262
FT /note="Translation elongation factor EFTu/EF1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03143"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN82859.1"
SQ SEQUENCE 282 AA; 30736 MW; 447B50015C8FA370 CRC64;
DEIVKEVSAY LKKVGYNVEK VRFIPISGWQ GDNMIDKSEN MPWYKGPTLL EALDMLEPPV
RPSDKPLRLP LQDVYKIGGI GTVPVGRVET GTMKPGDVVT FAPANVTTEV KSIEMHHEQL
VEATPGDNVG FNVKNVSVKD IRRGNVCGNS KNDPPKEAAD FTAQVIILNH PGQIGNGYAP
VLDCHTCHIA CKFAEIESKI DRRSGKELEK NPKSIKSGDA AMVRMVPQKP MCVEVFNDYA
PLGRFAVRDM RQTVAVGIIK AVTKKEGGAG KVTKAAAKAS KK
//
