ID Q4CRJ5_TRYCC Unreviewed; 843 AA.
AC Q4CRJ5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 85.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN82897.1};
GN ORFNames=Tc00.1047053509411.10 {ECO:0000313|EMBL:EAN82897.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN82897.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN82897.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN82897.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN82897.1}.
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DR EMBL; AAHK01002269; EAN82897.1; -; Genomic_DNA.
DR RefSeq; XP_804748.1; XM_799655.1.
DR AlphaFoldDB; Q4CRJ5; -.
DR SMR; Q4CRJ5; -.
DR PaxDb; 353153-Q4CRJ5; -.
DR EnsemblProtists; EAN82897; EAN82897; Tc00.1047053509411.10.
DR GeneID; 3534290; -.
DR KEGG; tcr:509411.10; -.
DR VEuPathDB; TriTrypDB:TcCLB.509411.10; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4CRJ5; -.
DR OrthoDB; 138489at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628:SF27; EXO-ALPHA-SIALIDASE; 1.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..461
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..775
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 89498 MW; BF75A248A6F868BA CRC64;
MLSRAAAVKA PCTHNRRRVS GSSGRRREGG ESEPQRPNMS RRVFTSAVLL LLVVLMCCGG
AATAEVGSNA DASTPSGSAL TGVIAGEGST SGGVEGLQRV DLFVPQTTQV LPKKGTESGR
RDSFVSPSLV SAGGVIAAFA EGHINAKPPH NESTKPSSDV VAEYIDSAWE WPTLVEKVGK
GTRSAHTVLG KAEGKGSLDV VHHPTTTMKG NKVFLLVGST ALSPVNGSWK EGSLELKLVV
GEVTKPSAGG EPSEWIKWDE VQSPVQQTTL AAHKGNLTEF IASGGSGVLM EDGTIVFSLM
AMNEKNEVDV YSMIIYSKDN GSTWSLSNSV SPAKCGSPRI TEWEGSLLMI VDCESSQRVY
ESRDMGTTWT EAIGTLPGVW VNSGSEASQD SSLHVDALIT ATIGKRKVML YTQRGYATEE
NANPLYLWVT DNNRSFSVGP VGMDNAGKKE VASTLLYSDG KLHLLQRRVS GEGSAISLSR
LTEELKEIES VLSTWSQKDV FFSSFSIPTA GLVAVLSNAS ASDDTWNDEY LCLNATVTNA
TKVKDGFLLT ETDSGVMWPV NIPDGNVRHV SLNHNFTLVA SVTIEEAPSE NTPLLTALLG
DFGPPYFMRL SYTADNKWET MPKGEAKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES
LGEEAPLTGG TPLEPFGFCF GACDFGDDDD GDGDEEASQE ESSLKEASPK KIGKKPRVTV
TNVFLYNRPL NSTEMRAIKD RIPVSTRAPE PQVKIAPKPV APAAPAAPAV PGPREVPAAP
GRTTVGRTAN TQHAPAGRLT SAGNEGTARE KGDGGANGDA GSAYGRVLLP LLLLLGLWGF
ATA
//