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Database: UniProt
Entry: Q4CRJ5_TRYCC
LinkDB: Q4CRJ5_TRYCC
Original site: Q4CRJ5_TRYCC 
ID   Q4CRJ5_TRYCC            Unreviewed;       843 AA.
AC   Q4CRJ5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-NOV-2023, entry version 85.
DE   SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN82897.1};
GN   ORFNames=Tc00.1047053509411.10 {ECO:0000313|EMBL:EAN82897.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN82897.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN82897.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN82897.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN82897.1}.
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DR   EMBL; AAHK01002269; EAN82897.1; -; Genomic_DNA.
DR   RefSeq; XP_804748.1; XM_799655.1.
DR   AlphaFoldDB; Q4CRJ5; -.
DR   SMR; Q4CRJ5; -.
DR   PaxDb; 353153-Q4CRJ5; -.
DR   EnsemblProtists; EAN82897; EAN82897; Tc00.1047053509411.10.
DR   GeneID; 3534290; -.
DR   KEGG; tcr:509411.10; -.
DR   VEuPathDB; TriTrypDB:TcCLB.509411.10; -.
DR   eggNOG; ENOG502S3YU; Eukaryota.
DR   InParanoid; Q4CRJ5; -.
DR   OrthoDB; 138489at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628:SF27; EXO-ALPHA-SIALIDASE; 1.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          127..461
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          687..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          747..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..713
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        755..775
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   843 AA;  89498 MW;  BF75A248A6F868BA CRC64;
     MLSRAAAVKA PCTHNRRRVS GSSGRRREGG ESEPQRPNMS RRVFTSAVLL LLVVLMCCGG
     AATAEVGSNA DASTPSGSAL TGVIAGEGST SGGVEGLQRV DLFVPQTTQV LPKKGTESGR
     RDSFVSPSLV SAGGVIAAFA EGHINAKPPH NESTKPSSDV VAEYIDSAWE WPTLVEKVGK
     GTRSAHTVLG KAEGKGSLDV VHHPTTTMKG NKVFLLVGST ALSPVNGSWK EGSLELKLVV
     GEVTKPSAGG EPSEWIKWDE VQSPVQQTTL AAHKGNLTEF IASGGSGVLM EDGTIVFSLM
     AMNEKNEVDV YSMIIYSKDN GSTWSLSNSV SPAKCGSPRI TEWEGSLLMI VDCESSQRVY
     ESRDMGTTWT EAIGTLPGVW VNSGSEASQD SSLHVDALIT ATIGKRKVML YTQRGYATEE
     NANPLYLWVT DNNRSFSVGP VGMDNAGKKE VASTLLYSDG KLHLLQRRVS GEGSAISLSR
     LTEELKEIES VLSTWSQKDV FFSSFSIPTA GLVAVLSNAS ASDDTWNDEY LCLNATVTNA
     TKVKDGFLLT ETDSGVMWPV NIPDGNVRHV SLNHNFTLVA SVTIEEAPSE NTPLLTALLG
     DFGPPYFMRL SYTADNKWET MPKGEAKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES
     LGEEAPLTGG TPLEPFGFCF GACDFGDDDD GDGDEEASQE ESSLKEASPK KIGKKPRVTV
     TNVFLYNRPL NSTEMRAIKD RIPVSTRAPE PQVKIAPKPV APAAPAAPAV PGPREVPAAP
     GRTTVGRTAN TQHAPAGRLT SAGNEGTARE KGDGGANGDA GSAYGRVLLP LLLLLGLWGF
     ATA
//
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