ID Q4CRY9_TRYCC Unreviewed; 1046 AA.
AC Q4CRY9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN83041.1};
GN ORFNames=Tc00.1047053511833.10 {ECO:0000313|EMBL:EAN83041.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83041.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83041.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83041.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83041.1}.
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DR EMBL; AAHK01002206; EAN83041.1; -; Genomic_DNA.
DR RefSeq; XP_804892.1; XM_799799.1.
DR AlphaFoldDB; Q4CRY9; -.
DR SMR; Q4CRY9; -.
DR STRING; 353153.Q4CRY9; -.
DR PaxDb; 353153-Q4CRY9; -.
DR EnsemblProtists; EAN83041; EAN83041; Tc00.1047053511833.10.
DR GeneID; 3534475; -.
DR KEGG; tcr:511833.10; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4CRY9; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 103..438
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 730..958
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 112592 MW; 2E0CC115362B2DA1 CRC64;
MLSRVAAVMA PRTHNRRRVT GSSGRRKGGR ESEQQRPNVS RHLFHSTLLI LLVLMCCSGG
TASAGESNVK KAVDALRGIG WEKLDNWKDV FDAGGKYGSI RGPSLVEVQG HVFAIAEAHC
KDGGDCSKFS FTGIASKYLG LSGVAGPTEI LTANASIFGA DPLKEGSGGI HTTNGITRPT
TLVIEDSVYV LLGNYSRAKP PVGGTNEPGL LLVRGTVTDE GRTKKIKWNE THVVNPQGKR
ESVSLTELIG GGGSGAVMRD GTIVFPMQAK NSDEERILLS MSFTPSDKKW ELSHTATGKG
CRDPTLVKWE KYEYGEELFM MAHCAGGYYD VYSSTSDGYG WNTLGEPINR VWGNSHNRKG
YGVQSGFTNA IIEEKEVMLI TAPVYAKDNE GGKGRLHLWV TDKARVYDVG PISREADDAA
ASSLLIKDEN KELISLYENK KSDGSYNLVA VRLTGKLERI KEVVKKWKDL DSALRTCRSG
SSGTVDLPTK GMCNGPVPTD GLVGFLSGNF SENTWRDEYL GVNAIVHGPA EKRIVVPNGL
TFKGSEAGAV WPVGDMGQTV PYYFANNEFT LVATVSIHEV PQSGSSPIPL MGVRMNDTSS
TVLFGLSYTH DKKWLAIPGD GEYFDDWEPN RAYQVVLRMD YYYWTVFVDG EEIHHTEYNT
SLFDSHRISH FYIGGDSKDQ SATGGRVTVT NVMLYNEELS EDDLNELPDS KVTIPSLGVE
EQPTGQAAST DDSVASGSRS KESATAEKLT EGDRDKQDEE SVLNLVPVAP PSTVVAGSSV
PKPATAAESA ENSLPDDNIQ LSGGEKSQQF TPTGEKESMQ RDSDAQTQDL QSAESTEFND
VEMSSESNDT EQTVEEGEAN DKSGGTTSSV AVSSDMDPTT ETVDGEHQVQ QSVELSSENN
EVRSTGTGTT GTERNLSLEA RDGNSERTMG SDSSLTPSKS DAETTSAENT DDVSRTEGDE
FPVENGEEVP QTVDTASGNA STLPGETEIS SKSNATAPSD AGILLENGHY SELAGMALFA
ESTVHGFVSR MLLPMLLGLW GTAALC
//