ID Q4CSR5_TRYCC Unreviewed; 811 AA.
AC Q4CSR5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Ferric reductase, putative {ECO:0000313|EMBL:EAN83317.1};
GN ORFNames=Tc00.1047053507665.30 {ECO:0000313|EMBL:EAN83317.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83317.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83317.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83317.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83317.1}.
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DR EMBL; AAHK01002092; EAN83317.1; -; Genomic_DNA.
DR RefSeq; XP_805168.1; XM_800075.1.
DR AlphaFoldDB; Q4CSR5; -.
DR SMR; Q4CSR5; -.
DR STRING; 353153.Q4CSR5; -.
DR PaxDb; 353153-Q4CSR5; -.
DR EnsemblProtists; EAN83317; EAN83317; Tc00.1047053507665.30.
DR GeneID; 3534821; -.
DR KEGG; tcr:507665.30; -.
DR eggNOG; KOG0039; Eukaryota.
DR InParanoid; Q4CSR5; -.
DR OMA; THALKSH; -.
DR OrthoDB; 156159at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972:SF207; FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 1-RELATED; 1.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 545..647
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 811 AA; 89831 MW; 7D7C3A5361CE060D CRC64;
MKEKQEGHTN KHTRLRRAMS VHTPFLSPPQ YPKDPQWGTI GLMAAGVICS GIASMGLSWW
HNADYFHHQG SYSRGWVGYD VFTFIGLLLF TVFAPVGVTL LYMGVSALLR VWNNRPGMVA
FGLVGAVFTA VGCLGMFWGK ETMQCLGIFC VDSTKYVEVP GLRPEAGIGF LSVTGITVFF
SLVPMGLVML LQVALRMTGL DRRWLAPIRQ KLCVKRVVVV PFAAGAFVLA ACWAIITFYV
PNSWEYFSAS RIARNAQLHA TGNYTLCRTA RNNFTCPELP WAWVFTRNWV SSDSVVLKMY
PSNIFFFSYL LILLLTVTVI RASRAGRRFL KWRCPLLRCF TLGEASFAFL TLAMLLLFFL
YWIQAHNFNM SWTGGSDAGI KASERWARAL GQLAVALLSL LMFPASRFSA LHSILGTSWE
SSIWVHKVLG YGMLLATVGH MVAFYFFYGQ TGTFPHDIFS IPMNIPMAAS NFTVPLISLT
TWFMIVAVGL FALEPVRRRF FELFYYLHIL SFYMIAPTVL WHSAAAWEYF LPGLTVWFVD
RLLRMHRSAS TVEVVSAVAS GSFVELSFRH ASLSAAPGQY AFVNIPELSL LQWHPFSFSS
ACEGCYTFHI KAMGDDSWTG HLVKLVSERG SSLSLSVDGP CGRVHEFDDY SVVVLVAGGI
GVAPCAAIYS HLRRQRMGGS WAPAVTLLWT VRDAELVPMM SHLWSDGGDT SVASNSSLEH
SIVSCSRNTA GELPSLRLFL TGESACGTLP QRKIDVSTGR IDAAVEIPFV IGDADPRTVL
VFACGPAGLV RSARDAALSL GVDFHEETFL L
//