ID Q4CSU3_TRYCC Unreviewed; 769 AA.
AC Q4CSU3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 83.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN83344.1};
GN ORFNames=Tc00.1047053505779.10 {ECO:0000313|EMBL:EAN83344.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83344.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83344.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83344.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83344.1}.
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DR EMBL; AAHK01002081; EAN83344.1; -; Genomic_DNA.
DR RefSeq; XP_805195.1; XM_800102.1.
DR AlphaFoldDB; Q4CSU3; -.
DR SMR; Q4CSU3; -.
DR PaxDb; 353153-Q4CSU3; -.
DR EnsemblProtists; EAN83344; EAN83344; Tc00.1047053505779.10.
DR GeneID; 3534852; -.
DR KEGG; tcr:505779.10; -.
DR VEuPathDB; TriTrypDB:TcCLB.505779.10; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4CSU3; -.
DR OrthoDB; 122794at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 129..463
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 84400 MW; 26A686814DD518A2 CRC64;
MLSRVAAVKA PRTHHRRRVT GSSGRRREGR ESESRRPNMS RRVFASAVLH LFVVLVMCCR
GAASSEMGTA VVEPTSPMPS SKVLIDGGGS VSEKEQPLQR VDLFVPNQTL VLQKGGTSPE
TTRDSFVSPS LVSAGGVIAA FAACHMDFEK PTDASLKPSF GVVAVYVNSA RSWPALVAEV
NNSTWKAHTV LGTAEGKESL GGLFNPTTTT KGNKVFLLVG SSDAHKKGLD WKWDSLKLKL
VVGDVTKPTA SEPSQRIEWT ESKSLWSQVS VSAHERQFKG LLPSGGSGVV MEDGTLVFSL
MAGDKSGNIC SMIIYSTNNG STWTLSEGMS PADCRYPHIT EWEGSILMIV DCENGQRVYE
SRDMGGSWTE AIGKLLGVWV NARSGGSWDE GLRVGALITV TIEGRKVMLY TQRGNFWKGQ
REMFNALYLW VTDNNRSFHV GPVAMYNNKN WDLASNLLYS DGSLHLLQRS INGEGSAISL
SRLMEELSTV KFFLVTWSQK DIFFSSLSIP TAGLVAVLSD AANNDTWIDE YLCLNATVTN
AKKVKDGVQL TESNSGVIWS LNTRDNNVRH VFLNHRFTLV ATVSIQKIPS KNASLLAAML
GDAGVAHFMR LSYTKDKRWE TVFKDQTTPK GSTWELKKEH QVALMLQSQK VSVYIDGELL
GEEEVLFTIR TPLEFVDLCF GACGEENPSQ ESHVTVTNVF LYNRPLNSTE MRAIKDRVPV
PTRGPESEVE GGTERRHIPR IDGVRANAPA GSGLLPLLLL LELWVFAAL
//