ID Q4CTQ6_TRYCC Unreviewed; 777 AA.
AC Q4CTQ6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN83658.1};
GN ORFNames=Tc00.1047053510033.30 {ECO:0000313|EMBL:EAN83658.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83658.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83658.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83658.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83658.1}.
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DR EMBL; AAHK01001957; EAN83658.1; -; Genomic_DNA.
DR RefSeq; XP_805509.1; XM_800416.1.
DR AlphaFoldDB; Q4CTQ6; -.
DR SMR; Q4CTQ6; -.
DR PaxDb; 353153-Q4CTQ6; -.
DR EnsemblProtists; EAN83658; EAN83658; Tc00.1047053510033.30.
DR GeneID; 3535253; -.
DR KEGG; tcr:510033.30; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4CTQ6; -.
DR OrthoDB; 138252at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 97..448
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 82183 MW; 00E299E23AAF720C CRC64;
MLSRVASVKA PRTHNRRRVT GSSGRRREGG ESEPQRANMS RRVFTSAVLL LLVVMMCCGS
GGATATDNGG STPRTSPEKH FVWRDKNGEE TVSSLHVPSL VEVDGGVFTV AEAQLKEGEG
DFFTGIASEL LEWTDKESKE LDANKLKTQV LEECPAGNNS CASQTGAQEA SASQSRTKVL
VSRPTTVVNG SRIYMVAGNY SFEVTGTAGN TAAAAKWGLL GAVGRVTNDG SSGKKKIYWK
DAFVISLTDF EKHESLTGLI GGGGSGVKMK DGTIVFPVEG TKKDGNAVSL IIYIATEDGK
LSKGMTDGGC SDPSVVEWRE GKLMMMTACD DGRRRVYESG DKGGSWTEAL GTLSRVWGNK
HKGNEKGVGS GFSTATIDNR DVMLVTLPVY SNRRGNGKGE LHLWLTDNTH IADIGPVSGN
DDVTASSLLY KSAGSGDNNN EKLVALYEKK GDGKPSLGMV SVRLTAQLKR VREVLATWKE
VDDRVSKLCP STAARNPSTG NDCSAGKITD GLVGFLSKNF SGGTWSDEYL GVNATVKKGT
NGVATGYADG VTFRGAWAEW PVGSQGENQL YHFANHNFTL VATVSVHGEP KGDTPIPLMG
ATMNDKNTVL LGLSYNKEGK WQVLCGGKTT KELRSNSEPG TTHQVAIVLR NGEQGSAYVD
GQRVGDASCT LKNADSKGIS HFYIGGDGGS TGRKEDVPVT ATNVLLYNRP LDDNEIRVLN
ANKISIPKLT DLRTVAAGAT GVGTARHFGA NGDGSAVCGG GLLPLFLLLG LWGIAAS
//
