ID Q4CUE8_TRYCC Unreviewed; 784 AA.
AC Q4CUE8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN83900.1};
GN ORFNames=Tc00.1047053509377.20 {ECO:0000313|EMBL:EAN83900.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN83900.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN83900.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN83900.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN83900.1}.
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DR EMBL; AAHK01001864; EAN83900.1; -; Genomic_DNA.
DR RefSeq; XP_805751.1; XM_800658.1.
DR AlphaFoldDB; Q4CUE8; -.
DR SMR; Q4CUE8; -.
DR STRING; 353153.Q4CUE8; -.
DR PaxDb; 353153-Q4CUE8; -.
DR EnsemblProtists; EAN83900; EAN83900; Tc00.1047053509377.20.
DR GeneID; 3535582; -.
DR KEGG; tcr:509377.20; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4CUE8; -.
DR OrthoDB; 132249at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..784
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004236028"
FT DOMAIN 64..410
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 714..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 85762 MW; 44CA16AA74875286 CRC64;
MPSMSRRVFD PAVLLLLFVM MCCGSGAAPT EASNSGEKII FEVNDSFSDS MNATLVQAFH
SFRAPSLAYV SGVVVATVEA HYKNSTDQKS CVSITAKSMK SSGGTWTNGT AIVFDHYDVK
IDRLLSPTTI VDEKDAETNA LVGGYGTSTT PLTELAAGDY WMPRMADGVV PHYGDDEEKK
QFEWQNRSTS GVPYDFWDGT STKPKPFKQF LGGGGAGIRM EDESRYVLPI QALTHDGKNV
SLVILANGTY YGWEFSKHTS HYGCIQPAVL EWKEKKLIMM TSCDDGSRRV YMADEKGTWW
TEEYDTLSRV WGNSLARKGH GVQGGFVSAT IDEQKYILVS RPVYSGEEGK QETGRLHLWL
TDMQRIYDVG PISAENENVA ASTLLYATVE AQSLEGGEKK EEKKLYCSYE VAAGGDNYNI
AFVDLTEKLE DMKKVVAAWK EKDAYIAREY GCGNEKNKPR DCGEVLAEGL VGFLSNTSTD
STWADEYLGV NATITKGTKG KVTSTENGVS FEGFGAGAEW PVGKKGQNVP YHFANDKFTL
VATVSIDKEP NGSSSIPLMG VRMNDAQGTL LFGLSYTHEK KWNVTFSESL RNSSAYGYGV
GWETNKKYQV ALEMHHYDGV SVYVDGEEIY YTKDYEDGED YNFTQKLRTL LRSHGISHFY
IGGDNTSNSD EINVTVSNVL LYNRALNEAK LNALMKRNAV AAAAAKVPAQ EVAAQTTNVS
EPSRHPANVP VVTPEAQQDA TLSSRSQHSP AQTSESESGP ADSKQTSSDI IEPFTSAGAG
GHSG
//
