ID Q4CW68_TRYCC Unreviewed; 1430 AA.
AC Q4CW68;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Subtilisin-like serine peptidase, putative {ECO:0000313|EMBL:EAN84521.1};
GN ORFNames=Tc00.1047053511045.40 {ECO:0000313|EMBL:EAN84521.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84521.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN84521.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN84521.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN84521.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01001668; EAN84521.1; -; Genomic_DNA.
DR RefSeq; XP_806372.1; XM_801279.1.
DR AlphaFoldDB; Q4CW68; -.
DR SMR; Q4CW68; -.
DR STRING; 353153.Q4CW68; -.
DR PaxDb; 353153-Q4CW68; -.
DR EnsemblProtists; EAN84521; EAN84521; Tc00.1047053511045.40.
DR GeneID; 3536357; -.
DR KEGG; tcr:511045.40; -.
DR eggNOG; KOG4266; Eukaryota.
DR InParanoid; Q4CW68; -.
DR OMA; ECDSDHP; -.
DR OrthoDB; 5606at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR017294; Subtilisin-like_kinetoplast.
DR PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PIRSF; PIRSF037850; Subtilisin_rel_Euglen; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1377..1400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 210..543
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 219
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 269
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 502
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1430 AA; 160570 MW; EC6AB333261F4F90 CRC64;
MPFPFFLLFL NEADQKKKEE GKGMRCRQIG STFTKHFHHL AGNSFCVFLL LLLSQTLLVR
GGVQSPVPCD SGFGRDYIVF INTYLLPDGT INVAKETQRW WKWRQADKTC GCLSIAPHVS
KGGGWQDFVV VRVLSPQRNR SMRCVQTELR DVRLVFPCVG QISVLRVVEN TFLWGNRTLA
SVAQQTGFAT ARPLYPRRYF GLSSTLKWTG RGVRIALLDT GLDSHLLLSE SSSLEQQRDS
NGTGGTRKPL LMCTSFVPGF SCENNQDGHG TFSVSLMAGN ISLLEWNRNK SVLEAKHMRS
DDKFIAEKTG LLSARSQYLG MAPGADVHML RVFDDNRDTR TAWCIAALNF ALQWGANIIN
LSFGGIDYYD AVFTEKITEL ATKGVVVVAA TGNEGPRMGS VHNPADQNEV ISVGSLGTRG
RRLISRRDYY YDDDNTEMNK SSIRLPVRWV STFSGRGPST WEMPYGTGRP RPDLVALGEH
VLGVGRDEGS GTLSLRVSHG TSVAAPIVAG IVALCIDALQ RLHGNWKANM NVAVIKRVLM
ETAVEIHPRL SALRVMEAAL HKEEKELLAQ RKCDWWRRGR NAFHRRDGIA ITRTLFHYRN
VLQYSRMSQG AGEVCPMCAL SWIAEEGQNR KLLSGFAFPR EIEATGEHQL PYGEASPTSL
PPCLLNWPYC EQPLFPSATP VEYNINIYYP QCPAARLAQA TPWIRMTSAR GICSAHRREQ
CQASIVDLTT AKQLLFLRAH APQTLEAYSG VISLFALSPS NASNVRLTSS ATEILEADDR
ERVLGHFDLI EVSGNVNVVY SCNASFHGIL RGTKEDETRF ASEWVTIPFR ISIVPRPSRA
QRMAFDINHQ WFYPPDFIPG DDSRPEPMHN KEHQHMKRRA LRESHGVFEC DSDHPHTNMA
PLLLYLRREM KLFVELPLLS YLSFWLHRNE TVPTPSLHWR NASRSYYSSI GTLLLLDPEL
PLLKEERAVF VDAVLLYQLN VVIISEWYSE QVARGLSFYD FTRNRTWSPL FLTKRGEMVE
STIVDEDNER NSHGLKGACH VPSLNKFLCE ISEGLLQLDE ERVVDGELVL ATSSSFFRHH
TGWGEQTVYR HFARMISAGM LRWPPAGSGC FARAPPCGEI ARTTMVCGME RAWANELHEF
TKSEGRTRGD EASNEAADVW RQVDPGGFIP LFGFVGVGNS DTDEECGRSS ADGMKRCGRG
RGRVAVFTDT SGFGSSSASL QASLRVLDKL FYDVSSQLSG NTGVEVVVPP RVREAIKNLV
THESEAPSFT FSIIRDFFHF VYTGDVPEFT NGAECKRSNG HMHAVTTPVE VNVREYEENE
YEELLSALFA SAPRRVAVAR RLREVFSGWE TAVTVADDDC IFRNNEFHFK EKNSHEAAMG
LVLFVCLSLV VLGLTFILLW KRKRVHCAFR GILKSDKGYS KRKKEEKKGK
//
