ID Q4CWN9_TRYCC Unreviewed; 1398 AA.
AC Q4CWN9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Kinesin-like protein, putative {ECO:0000313|EMBL:EAN84693.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053511253.31 {ECO:0000313|EMBL:EAN84693.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN84693.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN84693.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN84693.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN84693.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01001618; EAN84693.1; -; Genomic_DNA.
DR RefSeq; XP_806544.1; XM_801451.1.
DR AlphaFoldDB; Q4CWN9; -.
DR SMR; Q4CWN9; -.
DR PaxDb; 353153-Q4CWN9; -.
DR EnsemblProtists; EAN84693; EAN84693; Tc00.1047053511253.31.
DR GeneID; 3536573; -.
DR KEGG; tcr:511253.31; -.
DR eggNOG; KOG0161; Eukaryota.
DR eggNOG; KOG0241; Eukaryota.
DR InParanoid; Q4CWN9; -.
DR OrthoDB; 125885at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR047149; KIF11-like.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47970; KINESIN-LIKE PROTEIN KIF11; 1.
DR PANTHER; PTHR47970:SF25; PUTATIVE-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 32..398
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 435..564
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..706
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 132..139
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
FT NON_TER 1398
FT /evidence="ECO:0000313|EMBL:EAN84693.1"
SQ SEQUENCE 1398 AA; 159044 MW; 5B2B11241FFBFB5F CRC64;
MSSRTKTTPR PRNTAAGLTP MDDESNIGES ESVKVSVRVR PFDSRETSAS LISVLAMNSK
NRTVTIFNSL PKENNAITRK KTFQFDHVFW SLDSPDESGG EPVGQAEVYA TIGRPLVAHA
FNGFNSCLFA YGQTGSGKTY TMMGADPNAV GGADAGVTPR LCLELFQMRE RIEAEGHSKW
SVEVGYIEVY NERVSDLLAK RKKGSKEEVF VDVREHPTRG VFIEGQELRE VSSLDEVLGL
IEAGNRVRHT AATKMNDRSS RSHAIFMLLL REERSMQAAT GQTITTAGKN SRMNLVDLAG
SERVAQSEVV GQQFSEARHI NLSLTTLGRV IDMLADMTKN KDSQWSMPPY RESKLTFLLK
DSLGGNSKTF MIATVSPSGM NYEETLSTLR YASRARDIVN VTKVNEDPRA RRIRELEEQM
EQMRKDIQGK DPAYVAELEE KLRLLEAETQ KRAADLQALE REREKNEIHE KMLRATEAER
QELLSRAGAL ERQAFELSRN NEKLLREREE KERRLLEQMR RREAEMENNQ ERWNTALERE
RVLVLQLRRD CDFYRVQLEA MESRYGLTVD YVECLVEISK IFYEKGAASV MKCQLAQLRE
SEAKWVSSMK ALRKDHDNVA VERARLSESL RTMETKNKEL DAANEALAVQ LAQVEGEILR
LQDRFTNTVS DRDALAEHLQ VIEVTKAELE TLYNESNKKC EEFERKLNSP PVCTHHSKKF
EGEEWDALLH GRPSEMLDVF TNDVSTACRV SKDSVNNVTF ALGSLTCEFD VTHDADTTAA
DIDKRIAEHP FYLMQKLYDN RYGEKKGIDK ATDEIKRLER QLQKNVKDVD EKAKKIEEIE
NQKEELVQEN HKQKETNIVL QKKLETNAEI HEKIVKQLHD AIKNNTSLTN TLQNLEKNHK
NIERELELVT AEREELAENL RATEDAKAEV ERNLESVTAE REELVENLRA TEDAKAEVER
NLESVTAERE ELVENLRATE DAKAEVERNL ESVTAEREEL AENLRATEDA KAEVERNLES
VTAEREELAE NLRATEDAKA EVERNLESVT AEREELAENL RATEDAKAEV ERNLESVTAE
REELAENLRA TEDAKAEVER NLESVTAERE ELAENLRATE DAKAEVERNL ESVTAEREEL
AENLRATEDA KAEVERNLES VTAEREELAE NLRATEDAKA EVERNLESVT AEREELAENL
RATEDAKAEV ERNLESVTAE REELAENLRA TEDAKAEVER NLESVTAERE ELAENLRATE
DAKAEVERNL ESVTAEREEL AENLRATEDA KAEVERNLES VTAEREELAE NLRATEDAKA
EVERNLESVT AEREELAENL RATEDAKAEV ERNLESVTAE REELAENLRA TEDAKAEVER
NLESVTAERE ELAENLRA
//
