ID Q4CYH5_TRYCC Unreviewed; 455 AA.
AC Q4CYH5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=tRNA-binding domain-containing protein {ECO:0000259|PROSITE:PS50886};
GN ORFNames=Tc00.1047053508321.50 {ECO:0000313|EMBL:EAN85328.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85328.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85328.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85328.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85328.1}.
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DR EMBL; AAHK01001449; EAN85328.1; -; Genomic_DNA.
DR RefSeq; XP_807179.1; XM_802086.1.
DR AlphaFoldDB; Q4CYH5; -.
DR SMR; Q4CYH5; -.
DR STRING; 353153.Q4CYH5; -.
DR PaxDb; 353153-Q4CYH5; -.
DR EnsemblProtists; EAN85328; EAN85328; Tc00.1047053508321.50.
DR GeneID; 3537363; -.
DR KEGG; tcr:508321.50; -.
DR eggNOG; KOG2241; Eukaryota.
DR InParanoid; Q4CYH5; -.
DR OrthoDB; 1341752at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd02799; tRNA_bind_EMAP-II_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR002547; tRNA-bd_dom.
DR PANTHER; PTHR11586:SF46; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1; 1.
DR PANTHER; PTHR11586; TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER; 1.
DR Pfam; PF01588; tRNA_bind; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50886; TRBD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00209}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00209}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..394
FT /note="TRNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50886"
FT REGION 246..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 49580 MW; 8DFEFE79F1F715FD CRC64;
MEGGPMVICL FSFKLFSLPF YFSIYLFLQT KRLETTMSHM YILQGNSPLS KAVLCVLRMF
SVPMEQILTD GTHFAVNDGS VIHIGLLPIL MVLRKSSETP ELRAFVGAEA EVLPLVNQWI
STALLLSADA AGARATACAT TPLATHFFAE IERCVESFKL KNGFLAGTPR ATVADLLLYA
AIHGHPNGLT EALPSTLAWS HHAQQDAYLE PILSAPTAKA TAAAPNASKV KKTIYVKPSE
EEILRRRQEK EKEQKAKLAQ AANASTAATS SGTKDGHTQK GGQKEQSQQA AAPDPNQIDI
RVGRFKNIKR HPDADRLYVE EMDLGTETRT IVSGLVGHYT AEELEGSLCL TVCNMKPKPL
KGINSEGMIL CASNEAELRL VQPPDGAKPG DRILFADAFN AEALKKTKQL SRHVMGDLIG
FLHTDGEGIL RWRDIPAQHA HGVVRVPDIT NAIVK
//
