ID Q4CZ05_TRYCC Unreviewed; 872 AA.
AC Q4CZ05;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN85507.1};
GN ORFNames=Tc00.1047053510061.30 {ECO:0000313|EMBL:EAN85507.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85507.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85507.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85507.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85507.1}.
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DR EMBL; AAHK01001411; EAN85507.1; -; Genomic_DNA.
DR RefSeq; XP_807358.1; XM_802265.1.
DR AlphaFoldDB; Q4CZ05; -.
DR SMR; Q4CZ05; -.
DR PaxDb; 353153-Q4CZ05; -.
DR EnsemblProtists; EAN85507; EAN85507; Tc00.1047053510061.30.
DR GeneID; 3537570; -.
DR KEGG; tcr:510061.30; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4CZ05; -.
DR OrthoDB; 132448at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..528
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 79..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 94235 MW; C7ED1DDC3C0F577D CRC64;
MTRSLRGCSA LLLTDLSGVL PLLLLYSPIV VNRHVRKESK QALNATVKFE GTERTNSTHT
AHTHIDVLSR VAAVKAPCTH NRRRVTGSSG RRREGRESEP QRPNMSRHVF TSAVLVLLVV
MMCCGSGGAA LAEKAPGQES SPSSSFGWRD AKGETVSSLY VPSLVEVNGD VFAVAEAQCR
SNGVIFSCIA SQFMTLDGKN PTALETTRVK TEVLEECSTA EGECQSQSEK RTDSRSRTRV
HVSRPTTLGR ENDIYMLAGI YINDNFLSCK EGTSDGAPWG LLLVKGNVSG DNQKEKRVYW
NDTYVIPCSV IGENDDFLTG HIGGGGSGVR MDDGTLVFPL EAERKREEGD AEKDGKNKNV
SLILYKLDDA NWKLSKGMSD DGCSDPSVVG WKDKLLMMTA CDDGRRRVYE SGDKGDSWTE
ALGTLSRVWG NDQKRHEKGI GSGFITAKIE NRDVMLVTLP VYTKKEKNGN NNGKGVLHLW
LTDNTHIADI GPVSGEAEDV AASSLLYKSA GSGDNNEENK EGLIALYEKR GGGQSPGMVS
VRLTEQLKRV KEVLATWKKV DDRVSKLCLT SRAAVSALTE NACTTDKITD GLVGFLSGNF
FWNTWMDEYL GVNATVKEGT EKKVTSTEKG VTFRGAWVEW PVGSQGQTVP YYFANYNFTL
VATVSIHNLP RGDNPIPLMG VRLDGGKKLV ELSYDSQNKW WVLCSDGTTK RLSSTWATET
QYQVSIVLQN GAQGSVYVDG QRVCGSAQRG LEATEPQEIS HFYIGGDGGS AGGQGDVSVT
VRNVLLYNRP LTFSGPDAEV EKDVGSPAGA VSRTKTGDEM KTEGKPATTQ QVPTAPDSHA
VGEAAGDGGT VRGSGLLSSL LLLLGLWGFA AL
//
