ID Q4CZP8_TRYCC Unreviewed; 832 AA.
AC Q4CZP8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Multidrug resistance protein, MATE family {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053508507.24 {ECO:0000313|EMBL:EAN85752.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN85752.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN85752.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN85752.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN85752.1}.
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DR EMBL; AAHK01001357; EAN85752.1; -; Genomic_DNA.
DR RefSeq; XP_807603.1; XM_802510.1.
DR AlphaFoldDB; Q4CZP8; -.
DR SMR; Q4CZP8; -.
DR STRING; 353153.Q4CZP8; -.
DR PaxDb; 353153-Q4CZP8; -.
DR EnsemblProtists; EAN85752; EAN85752; Tc00.1047053508507.24.
DR GeneID; 3537858; -.
DR KEGG; tcr:508507.24; -.
DR eggNOG; KOG1347; Eukaryota.
DR InParanoid; Q4CZP8; -.
DR OrthoDB; 161529at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR11206:SF153; ETHIONINE RESISTANCE-CONFERRING PROTEIN 1; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 345..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 92405 MW; 74EBB4AC1C34C8AF CRC64;
MHMNPTSSIS EKPMSTRRKM KRAEDTVRLE RSKLLLHRRE KTHCDEQRCY GAVISSTVRR
ASSVPVNRPW RIVTAHRSGS RDRELTIREQ TTRLAEEAKK TLFHGSFTSS HGAMFSVLPL
HRHEGRVKSI TRRHPSDTHT AEMEVLSPKK EKGIYTSAVD VAAPSVLKKE KGSSFLREHQ
SSPEPSSFTI EYITTANQRP RSADASLIKD GGLGSCVKEH DILRADSVRM AIKRPEKIGT
ASREFFSSPS IEKTQAEPAA RPDEKRMHMI NTEEASLRKE ETNFSLGSLP YIYADIKADE
GIPDKTSAHR ISFAEHVVIN DPDTYTEEEE EEEVEISYGD ALINLLTFSV PAALTIGFTF
AVTVVPLAFI GSYLGELYLS GASVGCFILS IFVLYPMIGM TFAMDTLCSH EYGRDQNSQE
LGLLLQRGIL INLLYLTPAC VALYNVDSFL ERFYGVEITR VARDFLHYMP LFMLPEMIFI
AFNKFLCNQM RPQMPMFALA AGFIITPFVQ MKLTPMGVRY SMLGMCITAW FQLVVVILMT
IYVPQTRHTL GKLRIVEALQ PSDVKGYLKL AIPSAVFVAA EASSFDLTVL LCVHFGEQAG
AAWSGIMNAL YIFAAFSGGL SAGACANIGR CVGCNEPTNA RTYVVASITL VLLVSSIDSA
LLYSFFDFFM SLFGTKGQTL QLARETLILL PIFHMADAVQ FTFQGIFSGL GKNHWGALIL
LSSLWGVGIP LAFFLGLYLQ YGIFGVCLGM TIALCIEAPA MVASGCMMDY PSVCDAFTFE
RISISEEEEE EAEEKCLTGE DVIRRSGIPV SLSDFGPRLV TDIGRIRVPQ HH
//
