ID Q4D0K8_TRYCC Unreviewed; 631 AA.
AC Q4D0K8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN ORFNames=Tc00.1047053508043.40 {ECO:0000313|EMBL:EAN86063.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86063.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86063.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86063.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86063.1}.
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DR EMBL; AAHK01001296; EAN86063.1; -; Genomic_DNA.
DR RefSeq; XP_807914.1; XM_802821.1.
DR AlphaFoldDB; Q4D0K8; -.
DR SMR; Q4D0K8; -.
DR STRING; 353153.Q4D0K8; -.
DR PaxDb; 353153-Q4D0K8; -.
DR EnsemblProtists; EAN86063; EAN86063; Tc00.1047053508043.40.
DR GeneID; 3538223; -.
DR KEGG; tcr:508043.40; -.
DR eggNOG; KOG0245; Eukaryota.
DR InParanoid; Q4D0K8; -.
DR OMA; SMTRQTT; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF601; KINESIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394}; Coiled coil {ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 1..352
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 563..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 387..414
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 475..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 563..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 61..68
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN86063.1"
SQ SEQUENCE 631 AA; 72043 MW; 0F6DF6CFB5B4CB6E CRC64;
KAQFEFDASL WSIPPEHRIV HTFHDTKRSD YATQKDVYEL IGKDLVPHVF DGFNSCILTY
GQTGSGKTYT MMGLYDPNAS CGGDGEEGII PRVSNDLFLI LTTKQAEEAK KTELHDRVRF
RVEVSFVEIY MERVRDLLDP ALKNSKGNEK LQDARIRQDP YSGPFVEGVT KYQVENWAQC
CLLLERGSMH RTTCATAVHN QSSRSHAIFQ LTVIQEQTIP AKDRYSRPTV RCRAGRINLV
DLAGSERGGF QDYVKESAAI NTSLLALRRV IDNLTERQNI LMEQAKAEIT GAYYQERTLP
QVPFRDSVLT WLLSDSIGGN ARTTMVATLS PLVKNYGDTL ATLQWSSKAR NLVTLVKVND
PLTTVTGGMA NKAGELHNAV RIQRQNMDSL RESLRQKQEF AEQLERESRS MTRQTTKNKE
VLSSVMRQFN AATVQRALHR AVWKKNMNVL KAHHDKLTSQ LCERNKEVEN VYMKQSAVKE
EMAALQQKLG EERQREEELR VMIAERESKD DAAESVFTAL EAEYNAALKQ LRTDVITQGD
AADAHSELPS ARRRVDAARQ NVDETNQKAD MMEAKIKESK QRSWREKIAQ DERDAMELRS
ERNELQRKLD DLRSQQEELR TALKKRNKGR K
//
