ID Q4D0T2_TRYCC Unreviewed; 1054 AA.
AC Q4D0T2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN86135.1};
GN ORFNames=Tc00.1047053510125.20 {ECO:0000313|EMBL:EAN86135.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86135.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86135.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86135.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86135.1}.
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DR EMBL; AAHK01001283; EAN86135.1; -; Genomic_DNA.
DR RefSeq; XP_807986.1; XM_802893.1.
DR AlphaFoldDB; Q4D0T2; -.
DR SMR; Q4D0T2; -.
DR STRING; 353153.Q4D0T2; -.
DR PaxDb; 353153-Q4D0T2; -.
DR EnsemblProtists; EAN86135; EAN86135; Tc00.1047053510125.20.
DR GeneID; 3538313; -.
DR KEGG; tcr:510125.20; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4D0T2; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..440
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 737..966
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..952
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1054 AA; 113622 MW; 20E39E74F5F6BA95 CRC64;
MLSRVAAVTA PRTHDRRRVT GSSGRRREGR ECEPQRPNMS RRVFASAVLL LLFVMTCCGI
GGTASAGEGN VKKAVDALRG IRWEKLDNWE DVSDAGGKYG SIRGPSLVEV QGHVFAIAEA
HCKDGGKCSK FSFTGIASKY LGLNVDAGPT EISTSDPVVF GADPLKEGSE GLHTTNGIKR
PTTLVIEDSV YVLLGNYSHT KPQVEGKNEP GLLLVKGTLA DEGGTKKIKW NETHVVNPQG
KRESVSLTEL IGGGGSGAVM RDGTIVFPMQ AKNSDEERAL LSMSFNPSDK KWELSYTATG
KGCRDPTLVK WKENKYGEEL FMMAHCAGGY YDVYSSTSDG VNWNTLGEPI NRVWGSSHNR
KGHGVQSGST TAIIEEKEVM LITAPVYAKD NEGGKGRLHL WVTDKARVYD VGPISREDDD
AAASSLLMKS GNEKLISVYE NKKGDDGSYS LVAVSLGKQL ERIKEVVKTW KDLDSALQSC
RSGSRGTVDL PTKGTCNGPV PTDELVGFLS GNFSENTWRD EYLGVNATVT NGERRVPNGL
TFRGPGAGAV WPVGDMGQTV PYYFANNKFT LVATVSIHEV PQSSSIPLMG VRMNDTDGTV
LFGLSYTHER KWGFTPHNEA SEGYEDFEDD DDEWEPNKTY QVVLRMDYYE WTVFVDGEEI
HNTEYNTSLF DLHRISHFYI GGDSKHQSAT GGHVTVTNVM LYNEELSEDD LDELPDSKVT
IPSLGVEKQS TGQVAGTDAS VASESRSEES ATSHEKLTED DTDKQEEESV HNPVPAAPPS
TVAAGSSVPK PATAAEIAGN SLPEDNAQLS EGRTAQQATP NEGNESMQRG SDVQTQDLQA
EELTEFNDVK GSSESNDTEQ PEEEGEANDR SSGTTSSVAV SSDMDTVAAP ADGEHQVQQS
VELSAENKNV QSTGTRTTGM EQSFSLEARD RSSERTMNSD SSLTPSKTDA ETTSAENTDD
ISRTEGEESS SEDVKEVPQT VDTASGNTNT TPGETKIPSG SNATIPSDTG ILLEHAHLGE
LSAMALFAES TVHGCVSRVL LLLLLGLWGI AALC
//
