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Database: UniProt
Entry: Q4D434_TRYCC
LinkDB: Q4D434_TRYCC
Original site: Q4D434_TRYCC 
ID   Q4D434_TRYCC            Unreviewed;      1099 AA.
AC   Q4D434;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE            EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN   ORFNames=Tc00.1047053509591.60 {ECO:0000313|EMBL:EAN87291.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87291.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN87291.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN87291.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC         phospholipidSide 2.; EC=7.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00034036,
CC         ECO:0000256|RuleBase:RU362033};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC       ECO:0000256|RuleBase:RU362033}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN87291.1}.
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DR   EMBL; AAHK01001058; EAN87291.1; -; Genomic_DNA.
DR   RefSeq; XP_809142.1; XM_804049.1.
DR   AlphaFoldDB; Q4D434; -.
DR   SMR; Q4D434; -.
DR   STRING; 353153.Q4D434; -.
DR   PaxDb; 353153-Q4D434; -.
DR   EnsemblProtists; EAN87291; EAN87291; Tc00.1047053509591.60.
DR   GeneID; 3539713; -.
DR   KEGG; tcr:509591.60; -.
DR   eggNOG; KOG0206; Eukaryota.
DR   InParanoid; Q4D434; -.
DR   OMA; GSIRLYC; -.
DR   OrthoDB; 275833at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006539; P-type_ATPase_IV.
DR   InterPro; IPR032631; P-type_ATPase_N.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR032630; P_typ_ATPase_c.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 1.
DR   PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE IA; 1.
DR   PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF16212; PhoLip_ATPase_C; 1.
DR   Pfam; PF16209; PhoLip_ATPase_N; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362033};
KW   Hydrolase {ECO:0000313|EMBL:EAN87291.1};
KW   Magnesium {ECO:0000256|RuleBase:RU362033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362033}.
FT   TRANSMEM        75..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        291..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        334..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        857..875
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        922..949
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        964..987
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        994..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1038..1060
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   DOMAIN          32..98
FT                   /note="P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16209"
FT   DOMAIN          817..1067
FT                   /note="P-type ATPase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16212"
SQ   SEQUENCE   1099 AA;  125321 MW;  CC2983D1C515EA16 CRC64;
     MVYGKVRGCA WCCGCKRDED ELDDDEHVEV VVHMNDRKAN APYNYPDNFI RTTQYTLLTF
     LPLGLLMQFR KVSNFYFLIC MILALIPGVS PISPATAIAP LVFVIGVAMV KEAVEEFKRH
     RADRKANSIL VDILVNGKLE KVASRDLRAG DIVRVHNGEE VRADIFYLSS HTEEGQVFID
     TCNLDGETSL KGRKSIEVTR SLCSPEGLNA AQITMYTVPP EPGLLAWTGR IEIDGKDYAV
     DINQFLYRGC ILRKTDWLWG FVIYAGVDTK MFRNLRKRPP KSSDLDLKLN ILIIIVFVLQ
     NVFLFLLCSL SVWWNGRHKN HWYIRWYLEG HGKAAQWFLS YLTYFVLLSY LIPISLFVTI
     ELCKVIQAYW IRRDNKMMEM VNGRWRRCKP NTSNLNEQLA MVRYIFTDKT GTLTENAMKF
     KMGDIKGHLI YNENHSFSLE LLQRKGVVRT AAEEYFLALA ICHTIQPFPD ADAPLGVVYE
     GGSPDEVALV TTAAEHGFRL LERNSRCLTV EVEGERRVYD ILATLEFTPE RKMMSIIVQE
     RNTDRIILFT KGADSSVGSR TADEEDVQEY MQILSQSLLD MAEQGLRTLL IATRDLTSEM
     FSEWNTRFLA AGKVLVRRNE AVDRLCGEIE QELRLLGATA IEDKLQEEVP ETVSFFREAG
     VMMWMLTGDK RETAVTIAAT SSLLDPRRDY VVHVDLGSLD PKDPEAIEKI GADLHQVELH
     LERGRREGVR CTLVIDGTSL GVVMEHYFEL FVRLSKCVSS AVCCRLTPLQ KAEIVRMFQK
     LTGFTALAIG DGANDVSMIQ EARLGIGIIG LEGAQAALAA DYAIPRFRDL LRLCAVHGRY
     SLVRNASCIV VSFYKNFTLS FMQFIFAFYC GFSGLTLFDG WFLTFYNVMM TSIPPFFMGI
     FEKDLPSEVL THRPDLFTPL SHGLYFSCVV FLRWFLEAAF HACVIFYVIY PTMVNGDYNR
     QHDIYGIMVG SMSLFVLVSV VLGRFALQIR YWQLLQVLGI ILSVIVVFAF FTIYSAFPRI
     GDLSTYWQSY VLMSGAKFWL YQLLLFGSLI FIVDLTVLCF QKNLWPTPRD LAEREHLLLL
     ESKRRKREPA DQISNLGVV
//
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