ID Q4D5C1_TRYCC Unreviewed; 4433 AA.
AC Q4D5C1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE RecName: Full=HECT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053508111.40 {ECO:0000313|EMBL:EAN87725.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87725.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN87725.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN87725.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN87725.1}.
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DR EMBL; AAHK01000989; EAN87725.1; -; Genomic_DNA.
DR RefSeq; XP_809576.1; XM_804483.1.
DR STRING; 353153.Q4D5C1; -.
DR PaxDb; 353153-Q4D5C1; -.
DR EnsemblProtists; EAN87725; EAN87725; Tc00.1047053508111.40.
DR GeneID; 3540210; -.
DR KEGG; tcr:508111.40; -.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; Q4D5C1; -.
DR OMA; FSARTHW; -.
DR OrthoDB; 166249at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00094};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00094};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094}.
FT DOMAIN 1..185
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 601..631
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT DOMAIN 4072..4422
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 4390
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN87725.1"
SQ SEQUENCE 4433 AA; 494008 MW; ECE6B7C2DE79937F CRC64;
DLARTKLFRE NETPAFVPRW LGGATTVMGK GAFYGSSPMP ARGRHMIGFR IRRRQQEGRG
VGAPLGGCYY VGLTHGHPPV SNMTSLISRD DVYVLQDTDD QDQVPHLLLR RHCIPRSSQR
RIYGNDEIVW LELNADVGEI TYYRDKMVLI GLAFANISRV DDLYPFVFHF NEDASCELIQ
APTPIEDNCE LFLSGLRRSV AIHTLQQLHV VPYFGDVVSQ WIHRFLSRSH QDIDNSFLAL
AVLGGEKSCE FCLHETHGAV VVDSIFDVAS KAIVYLEADG DMRVFSTDLL DIKPSFVKPP
LFSLLETESL RCCGWLLAEL SRILFEASMI VPLMKYEEEK RGEIESQFFE VTREAMNLDF
VRGLNNLLQE NMDTIAMDLN STDMPLSLLQ STSSSFIMVD GRQPVSGTPV TIDQRLSTSS
LYTPNPSIGV TSGSGYSVIR GNVLLESFFT FTVSLTTKAS NDTLLYVGVS SETELFTDPQ
KVAHCKKTWA LCSHDAEESN SINCSVEPGM IFSSGYILFG SGDLIILQVD RREGTASFSR
IRSGKCVDFG VLFERIPERE KLRPFVLAGS DTVVVFSFLN SRVFPARNIF PLGMIAAWEN
HSSWVHCTSC EMELSKFWYE SEGGMYLCQE CFNSWRFPKI MFHLFQVEEP LLDYLVSRHS
PKELIVGDVV EFVENTVLTW LDDKGVNVNI EGGICMASDD LAFATLEPLN TFSNQRIDIS
LGHVAGVDGF PFGGLQPYSV QWRVGNILKS SRRVESDMLL VSSTVIPHGT RVVIELNFGA
SEEGRSLNKA GLFLGVTKLA SDYRAINMSE LERLIADHNI WGTWCDAKAK LSSSTTLYLL
VDTNRVSVLV SSSLSGLHMH PVVVSCNGLA EEETTLRFAI YSRDLCVVTS MSGFLSANNS
VVEPSISPLA VGFIQKGAIG PETDIMNSSF FLFDSVAQTL AHSGTFWQLM PIVTEEGSGV
LFAIGDTLTI TLDQSMLAVY RNGLPLAMCK VKKHQNFKPE QLVVYFSTRG MFATIVPPLY
GKSHLGRVVR TYGNDVGVVE CLCPCPGRRQ YAVRAKDVRF CALAADSTRL KVDARVAFKA
GSLNVPKRGT VVSIENNSAN VRDDEEKRIW FSLQLSSLYL VDNEGPHQVP QGLYSLPTLP
TSTVLRVFEV GKTKYRPQRN GSYNGIMFDL LAHDTIVLTG LSVMTHTTGR HRVEVFFKKG
SHHMHEREAT AWTKVFSNFV EMRSEHQFSV KFSGIHIESN ATFALYINAT HNCGVGHYSK
EDGCSGAISS KMDSDGILTV FVGRTSESSS PFLETVSTPR GFCGSIMYMQ TKDTRPPLIE
RTSSSLGCLQ NKNERYGDAI FLRSIPVSTR VVSNAEFFLE VFEGSILIQK VTFPILIGAG
VRHAMGSTHL SLSLFYSSLD GISGVKNAER EWIWAYNAML PLRNDICEFC MDGLSLLLKR
GKYLFVAICS KLKGVLEDGK GVKLSCFIQS SDESYVVKNS FYGVQGFAGD IVATTTSNIM
TCNEICSIFT GGRLNQNNSA SYNGIMFDVR SKRDVLLEEV FCVAQTTTDN VNVRVFWKEG
SMEGAEKTAS QWQEVISKDL HLSDKQSFSP GLLNLHLRAN QMYALYINTT SSCGVRFYNS
SDGHLGEVGD EFEDDGMLTI FVGKKSESPL PFAEIPAEPR ALRGRITYRA FMEKVFLAPN
QAVFPALKGL LVTRILAALI AYVGGASFAA TIFEDKSVID LLAKIATSST TAFCDAEAAG
NLLSSMMRGN FVEELRDGMV TLPLFTKKPT TFNVFGKGDL ALVANATETD LSGQMVRIVD
DPNENWHVLA RCEAIPNHHV TLSVDHLIPI IICPDCNLPF SSEGICQKTG KGHVPFLREE
DQLISIFTRY IFHQSRLSLV ASAVCARSLL LDPTTHTFCI DPKTHATRIE NCIDMSCCDR
CNLEYTISPE VLLEGTEELK SPGFVCPFRY HDTMGAFVSI SFSRISDSWK IMFLSDLPLR
VEKDTPLKVF AVSLEVILRD GTRQDLLSSP QMYYAVKGGP IHCELPTLAS SLHHLCIFSD
DRIHLCLVVK KMNLPSSIPL TLKSVDGWMW EGGRDTAQLQ PNKRCIFQGS FDFEKWPREK
PRFWQFSVTS ETNEKIFFLE VHVIVPKSMT TVFLDKIQNH VIRCSFSLSR NEVLSLAFTV
DGDFLIYDED DNIRCHVASD DLRLSSARGL PPKIAVMNVG ANPVIVHLHP PSAAKNARSV
TCFNDDATDP GSYLPEWVLY EPHNVSVSRN GLTARCCNEG GQAVIGSPLS MTGLSAFVIQ
MDRSDRTRGD SLGSGHFAGI VVSTFQELAP HFGAMCKHVD SVWAVQDVYD ADSLPTQETI
PPLGASTNQM FLVGTHLHFL LDREDGTLSL ARDNESPRVV FRNIPSNLPL SPFVRLDHAT
ASATLAAFSC KAWGNGGILT SPSMILSSQP ITPTILRRLP YHVVFSMFSV FRHVVNYLPS
QQVTLVEKAW SDRFNCSRFA YRLTCAVQIL VELGAFSRCM AYAEEEEAER FCSRDEVQNV
IHTLSESEKR AAVVYSDGNG EDNISLLLPE GYEIIGYMKD DSMIRLLYFD GDGPSERTLH
LFRFDDSEIC INSCNLVTKH VCVMHQEDII PSLGDSSWCG IITSGWFDCT LDSVSVDILN
EHQQRVIAMS ILGALEHWHL HSLPHGNVNF KNVYLRIIGE TVVACTLWNV HCLLRHHTCA
SPGLRIHGKR DMEGDRWSCA YILNRLSSLL KADVKFGNAV KLLMNENLKI SDAIDQTEIF
AEELRKTADG QVFCLRTGDH LGVGAGSYNG IMFDLVAKHV KVKVTRVSFV PDTTTLARVT
LFVRDGTFMG VESERTEWRL IMDQEMKLVD KRETELTEFD PVIIPAGERV ALFLHTTSGS
GVLFYSETDG VRANMAAVEE ENDHIGITVG KKSENVMPFV GIQNQKRLLK GSITYTLPSQ
AGGYRSRLRI LSHDNSTCLQ QKQQNLLGIP VIVAETRPGL IFDMNEDDYL VFMGEHCEWF
HKDLIRNACF TESSNLEELD LTLQKILCKR RKPPWGISHQ YLCYRQLVFH KRIQSNTETD
PSRPSVVWWI SDPITSSCIV SVWQVIAMAD TSFLLLLTSQ DLSLSQSSNQ ETLLSQGQAF
FYIDEWARSV ILSGNTGPKV VKQLQNSLSE NHLYLAFSSM DLEAMNAPVA AFLNRFTEDI
TVRSASDTTA LVSIRPGACL QEHIFLNGIV LKCSAEGGKT TTLSRATSLT SQRDVRVTQM
PCLHIPNENS GNFGSTLTET GVVEQSHPSH FFLEMELREL CISHDVILHT QSEFLDVSCR
CVRQIAHGGS FLCTVTKPVF CGEKVHEIEL LIVSTNRHSV QLSFQDVTTN WFLRVPLPLF
KHYENFYFSS SETVQCIHLR LCVFPQAKRA FVSVNGGMFY EVIPGYDCPS EFRLAISLSG
IASSVRFLHW RVFDRHSPVI TREMLETIWS RLRVGCISPN VSQSVGVLTR HSRTPANLVS
SRKTDVGLVS QIEAAMVSYA RQLLGTVILS LKSPCLHKGL HILLPFTPLR SDLNALEVLV
GAEMKRSSFS LLAFAYACLA TPTVAQSLEG VETSVNIIFL SLSNEKVLPF LSTAFGPTLT
LLLLRTATVY TRSIRHMALR CVLQLLKTDQ CALPSHEALC ASFDPLLGMM NGLCWKGRTS
SVVVQLGISL ICELIRRYQL ERSALTPPGK KSTVPYAIAA STKIVLAAIT SNPPVPLPDA
FTEEPKEAHR IEYELRTSTT SNEGIRSCYG VFSEKFRSTF GSKRFEVVLN PSRKGNVVVG
WDMNAALPGS LVSKPSQGDE MSRRIRLPSC GYFIDSSGKV YVCLSHKKES QPLKARAKGG
DTVSVKCLYH EQTVIITLQR GVRNESVTRF ETYPNEMLAL PVFFAEREED ATFNGEHLSD
VSTGMDIAQL YNTIQEFPDR LDTAVVPQGY DFYAELAHFC QTVMNSEKIC ALLENDAGTT
VRSHDLASFP LLSSFLGVGA FTNEIPLDPL IPYMRRLQVF DVITSVFSAV VDLRRKTELF
ELWKKLKFLC SAESSEKIQN ETMRPFRNRP GLKANVIIHT MQARPSMRLG PYPTLMRSVF
GQLFVQLQKS PISTFYASPM FAVKLAGFGS TDAGGPYRDI LSQLATEIMT THPNGTFQLN
PLFAQCGRGG QSAVMPNVSM ALNSQSSFMF EFFGKLIASC FLTKDLLAVE FPPLFWKCLL
SDETTSQDLL AIDPDIMRQL TPEDLMDRTA DELEERFPGI FESWSTFVTE NSQMNLGAEI
PPSTIRSAKI LGEHISTLEL HKYDVAISYI QRGFDEVVPL YTLNAFRWQQ VELIICGAPK
LSYDALREVC QVSLPANDAR MFLDVIASMT DEDRMLLLRF TTGQTRLPLK EAIKVQRNGA
HDSLPTSSTC FFTLRLPSYS SYESMREKIL YAIRQCKAID TDGQAREHIV LDH
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