ID Q4D5H8_TRYCC Unreviewed; 514 AA.
AC Q4D5H8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN ORFNames=Tc00.1047053510131.70 {ECO:0000313|EMBL:EAN87784.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87784.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN87784.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN87784.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN87784.1}.
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DR EMBL; AAHK01000982; EAN87784.1; -; Genomic_DNA.
DR RefSeq; XP_809635.1; XM_804542.1.
DR AlphaFoldDB; Q4D5H8; -.
DR SMR; Q4D5H8; -.
DR STRING; 353153.Q4D5H8; -.
DR PaxDb; 353153-Q4D5H8; -.
DR EnsemblProtists; EAN87784; EAN87784; Tc00.1047053510131.70.
DR GeneID; 3540271; -.
DR KEGG; tcr:510131.70; -.
DR eggNOG; KOG2094; Eukaryota.
DR InParanoid; Q4D5H8; -.
DR OMA; QERDASC; -.
DR OrthoDB; 146204at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EAN87784.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transferase {ECO:0000313|EMBL:EAN87784.1}.
FT DOMAIN 117..299
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 514 AA; 57461 MW; FF7064C848A7F2F8 CRC64;
MQRCWARVSP AVFHRRIRGK KRAVDEVSSK LTLDATKAGL SGVNKARVNK VIEGCSKGSA
FYLNEERLEA QRKKRHMELL SKSEVYRHLS TADKQALKDK VEMCEVELEA GRHFRNYVHV
DMDMFYAAVE MKKNPSLVDV PLGVGTFDML STTNYVARRY GVRSGMPGYI GVKLCPSLVI
VPTDFDAYHA EAAVVRGIAA AYDPNFTSVG LDELTMEVTA YLQQHPGMTA GDVASEFRAR
VFAETQLTAS AGIGPTATLA KIASNYEKPN GQHELRLRTR QDVMEFMKDL PVRTVPGIGP
VQDAILRVLG IRTCGCMLRK KGLLCFLFPE KTFRFYLSAG LGVVRSNADL MRSDGTQKKM
GHEITFKRRL KSEAELKQIV LEVLVAVHNT LLLRRVAAQR VTLLMKRRTF ENHQFSLTLG
EATNDFAALR EATRKLLQPH LTSFDKFRLV GVRLGKLQST SCKKLISGVE ERKGRPPARI
TASVLSVERR PKTASHTRVL NAPSGNMNRV FFSI
//
