ID Q4D6J3_TRYCC Unreviewed; 787 AA.
AC Q4D6J3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN88145.1};
GN ORFNames=Tc00.1047053507819.30 {ECO:0000313|EMBL:EAN88145.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88145.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88145.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88145.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88145.1}.
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DR EMBL; AAHK01000927; EAN88145.1; -; Genomic_DNA.
DR RefSeq; XP_809996.1; XM_804903.1.
DR AlphaFoldDB; Q4D6J3; -.
DR SMR; Q4D6J3; -.
DR PaxDb; 353153-Q4D6J3; -.
DR EnsemblProtists; EAN88145; EAN88145; Tc00.1047053507819.30.
DR GeneID; 3540691; -.
DR KEGG; tcr:507819.30; -.
DR VEuPathDB; TriTrypDB:TcCLB.507819.30; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4D6J3; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 109..441
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 13..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 85117 MW; 43393AB4D906EE32 CRC64;
MLSRVAAVMA PRTDYRRRVT GSSGRRREGR ESEPQRPNMS RRVFASAVLL LLVVVMVCCG
TGGASNAVTS NSGNAQLPHT VVLFVPQKTQ MLPKDGTSQG TKRDAFVSPS LVSAGGVIAA
FAEGHMETEY QGAPLGKPSS DVVAGYIDSA WEWPTLVEKV KKEEWRAHTV LGKAEGNEGL
DVVLRPTTTM KGNKVFLLAG GFDVHNESGG NWKWGKFELK LVVGEVTNPT GGKLSERIEW
GPIRSPLSGS TMTAHQGNLK EFVAAGGSGV LMEDGTIVFP VMAKSGNGDF YSMIIYSKED
GEKWSLSTGV SPAKCFAPRI TEWEGSLLMI VDCEDEQRVY ESRDMGTAWT EAIGTLPGVW
VNSQSSFRDL NLHVDALITA TIEGRKVMLY TQRGNFSREE EANALYVWVT DNNRSFSVGP
VGLDAAANWM LASTLLYSDG SLHLLRRRGD YEGRAISLSH LAEELNKIKF VLKTWAQKDV
FFSGLSIPTV GLVAVLSDAA SDDTWYDEYL CLNATVTNAK KVDDGLQLTE PGSGAMWPVN
TWANNVRHVS LSHNFTLVAS VTIEEAPTAD APLLGAILGE TNSTHTMGIL YTADKKWVTI
FEYEKKPKSG TWELKKEYQV ALMLQGNKSS VYVDGKSLGE EELPLTGETP LELVTFCFGA
CGGHEQESHA TVTNVLLYNR PLNPTEMTAI KERIPVPKRA PESQAGGVPQ TIASAVSGPE
KNSAAPAVPM KLDSHAVEEV SEGGAAKKNT SRTEDVQFFV PEVSLNSAGS GLLPLLLLLG
LWGFAAA
//
