ID Q4D6J7_TRYCC Unreviewed; 1261 AA.
AC Q4D6J7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN ORFNames=Tc00.1047053511855.50 {ECO:0000313|EMBL:EAN88150.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88150.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88150.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88150.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88150.1}.
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DR EMBL; AAHK01000926; EAN88150.1; -; Genomic_DNA.
DR RefSeq; XP_810001.1; XM_804908.1.
DR AlphaFoldDB; Q4D6J7; -.
DR SMR; Q4D6J7; -.
DR STRING; 353153.Q4D6J7; -.
DR PaxDb; 353153-Q4D6J7; -.
DR EnsemblProtists; EAN88150; EAN88150; Tc00.1047053511855.50.
DR GeneID; 3540698; -.
DR KEGG; tcr:511855.50; -.
DR eggNOG; KOG1031; Eukaryota.
DR InParanoid; Q4D6J7; -.
DR OMA; MKSKQMI; -.
DR OrthoDB; 240919at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR038983; C2CD5.
DR PANTHER; PTHR37412; C2 DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR37412:SF2; C2 DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 1..107
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 734..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 140128 MW; F2C546FABA9CDD3C CRC64;
MATLKVTVHE AWDLPIMDRT TGLADPYVVL RLNDLEYTTE IVHMSRHPVW NTVFRIDTPD
LFILQEDPLE VRLYDHDIIS RDDIVGLTFI DCNSMVLQSN PSMSGWFPLF DTNAKGIRGE
IRLTLKIKFH NAENPLAPRL PIRYAPHFTL PDVDQRSRAE DHQLLLPNPQ LDMYLAEGFE
PLRATRMEHP SIAAEEEGIL IFSAWRLDPS VYRVESVLTM VEELIVKADP EHSKLTNLRS
TRSTNEARII QLYKLSGKVR RQLARKVVEM QCNAVLGYVE KFDMESNGII VRAYGTPCVL
SAVKFVDRER AERLLPDSTR VALRATEISS GSITPAHDPS VTTLHMQAAE SAGGLTAAGV
VLGSGMTFAS PMQQRTSAPE TSFLQLPEAE VPTPPQLASN NPPQTCLLSP AVYPQVTSMP
CDNYPMTLSK ADYGFPSLLA QQTATGARSN VLILTLKDLP SGMIEHIGGY ISARSVKIVA
KMKSKQMISQ ERDSWWMELR EELKANARAF HCNVILGYEE VVMYHEDVAV LSLSGTAVVL
NSTMLPLRCG PEYLYQTARG RFGAQKNCSM LHLFYPNLRL KDFVGEMECP AVCNLCHRKS
VPDVLLVSCT MPQDLMCEEQ PRLVHTVVSK AKSAVRGVDL ALAVSQALPY IEYSLHKQLI
FHLRLQKLNA VFGLRITVCI ASDTIIGTLT GTGVRLVALP VPSLPRLKFI DPAIQRNKTV
MRLVELVAQH TRLKRHQHRN FPPMGAEHQG SFSSSRSSSA VQMEDSNPFE TAGGDGELSS
ESGSDQGPHG IGRVSRACDY VLKIDDEEEA EMMLGMSADL TFEHSLLLTI PYVPEWANTY
GSQKRIVINR RFVFQRIHNE SVTTGKINEC FANAKKAFVQ VACRVAMRCC RCPLERLHVM
GFTFDFFFEP NSCSLQLRLE GCLMLRTTTQ RVRLMELEER SFMECMRRIE RYPLPGPIVY
GNPSGSADIH PPSQDTSTLP HGSLGSVPTL DGNRSSGFGS FGDGEKVMLR NIERRIFVMS
NAPYALPFVF ERHVSPPVLG SSEGTNSAPL TASDVYGYYK DNRARPGMME RQWQALALLA
STAVRNLMEK TGLNSDGKGG VDARHRDGAN SLKSTGSGGP ILHQPAQRLP MDLKTLEAND
SSIIFTPLDF VAGRSIARYV GRLSQHFIRE AYEIDSSEDL GVFFQKTEFE MQCLVQAMVC
LMGGNALLKH CVTYHEVWDS DGSGCAFVFV TVTGDVVQTT TLPLVTLLLS NGGSYEEGSD
D
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