ID Q4D6L5_TRYCC Unreviewed; 462 AA.
AC Q4D6L5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Threonyl/alanyl tRNA synthetase SAD domain-containing protein {ECO:0000259|SMART:SM00863};
GN ORFNames=Tc00.1047053504883.50 {ECO:0000313|EMBL:EAN88169.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88169.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88169.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88169.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Alax-L subfamily. {ECO:0000256|ARBA:ARBA00008429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88169.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000923; EAN88169.1; -; Genomic_DNA.
DR RefSeq; XP_810020.1; XM_804927.1.
DR AlphaFoldDB; Q4D6L5; -.
DR SMR; Q4D6L5; -.
DR STRING; 353153.Q4D6L5; -.
DR PaxDb; 353153-Q4D6L5; -.
DR EnsemblProtists; EAN88169; EAN88169; Tc00.1047053504883.50.
DR GeneID; 3540722; -.
DR KEGG; tcr:504883.50; -.
DR eggNOG; KOG2105; Eukaryota.
DR InParanoid; Q4D6L5; -.
DR OMA; CMHTSQH; -.
DR OrthoDB; 5490212at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:UniProt.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0043039; P:tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 2.40.30.130; -; 1.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR012947; tRNA_SAD.
DR PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR Pfam; PF07973; tRNA_SAD; 1.
DR SMART; SM00863; tRNA_SAD; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 233..277
FT /note="Threonyl/alanyl tRNA synthetase SAD"
FT /evidence="ECO:0000259|SMART:SM00863"
FT COILED 320..347
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 462 AA; 50560 MW; 619E4D793F087071 CRC64;
MSTAPTFVRV GELACQRNPF LRGLRARVVL CEPVSINKPA GGSGKGGHNS TNTNPSYNVV
LTDSVLFPEG GGQPCDHGTI VYGNEEVPVR NVQRRGDTCV ISTPCPLEVG EEVEVRVDWP
RRFDHMQHHS AQHLLSAVVE KAPQCRLPTV SWSLTHPYSF IVLPTGNKID SDVVAHLEKV
CNDAIARAVP VRCDMYPSKE AYEQALREKV EKEDSGEIFR QSRSIPSDVT GPIRIITVED
GIDQCTCCGT HVSNLTQLQM IKLLHQETKG DTLKLFFVTG DRLCRYYGDM YFREKELMKE
LGGVRPEEFV AAAVKRGKEY ADMEKRLKNL TLELMKAESE KLIAEAKASL AEGAGGGIVV
YRRDDVGGDF FNALRDAIRQ ACPECLAVLA WGSPVATTTA GGALGRAKTG QFMVIGPTDR
VESLAPSVCM ALEGKGGMSK YGYRGKGNLA GWDKLVQKLL LS
//
