ID Q4D7U0_TRYCC Unreviewed; 748 AA.
AC Q4D7U0;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN ORFNames=Tc00.1047053504047.30 {ECO:0000313|EMBL:EAN88589.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88589.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88589.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88589.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88589.1}.
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DR EMBL; AAHK01000864; EAN88589.1; -; Genomic_DNA.
DR RefSeq; XP_810440.1; XM_805347.1.
DR AlphaFoldDB; Q4D7U0; -.
DR SMR; Q4D7U0; -.
DR STRING; 353153.Q4D7U0; -.
DR PaxDb; 353153-Q4D7U0; -.
DR EnsemblProtists; EAN88589; EAN88589; Tc00.1047053504047.30.
DR GeneID; 3541209; -.
DR KEGG; tcr:504047.30; -.
DR eggNOG; KOG0240; Eukaryota.
DR InParanoid; Q4D7U0; -.
DR OMA; GIAHRMI; -.
DR OrthoDB; 129780at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF421; KINESIN-LIKE PROTEIN KIF25; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394}; Coiled coil {ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 3..316
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 472..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..385
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 472..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 76..83
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 748 AA; 83184 MW; D673C18F1C55A83B CRC64;
MSNIKVAIRC RPLFENERPA VGLEFYQGRR ILLDNKTYDP DHIFPPTSTQ DEVFAACQPI
LQSVKDGLHG TVMVYGQTGT GKTHTMLGVP GGTDGIAHRM IAAMLEHVQQ RTLEESKCAL
TLSMIEIYNE KLTDMLSENG DAEVTLVGGF PKAMVKLTLS RLSDANEAIQ RGLSWRHTAM
TLMNERSSRS HVVFILDLEE QNAYTDTVEL AHLFMVDLAG SESLKKSQVN GVAANEAGKI
NKSLLALKSV FLALANSNEA TRPSHVPYRD SKLTELLRDS IGGSARTLMI ACISAVGRDI
EETKSTLMYA VKARSIRNAA NTEREKLLVR LRSFELENQR LRNRLQERVV ERGGYYVNRE
EHERIQQLEE EHQALKVDLE DLLRERQQND ALQHINISQT AILQAMIEEK EDELCRFKQI
YHEALTQFDA QLCLLQRVVQ EAVSGAYEAA QRSAEVVAGR LEEWRVHALR EENEDGGLNE
EEKNGEGEGT RMARGQEGVL ALSRDYEKEA VRLVDRINDG FRSLSQEVLA VTQSHCATVQ
ALQERRQASL ESLQRTLQEQ VREVLSAYAR EQTRLDKELE DEHRLFESGI SVTANQSSSP
ADVLPFRHMV RNVCRDAVES SKEYFPPCSL DENLAESLRL INESFRVKAA SASLAALVQM
GNMPPSRSSN SSLSTTTTTN TATTTTPTAA NAMTATAAFV SSGDSQPSVL STKVVNRTAG
NNGGVKAKRL RSGSAMSDSR RTSARQEK
//
