ID Q4D995_TRYCC Unreviewed; 600 AA.
AC Q4D995;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=BD-FAE-like domain-containing protein {ECO:0000259|Pfam:PF20434};
GN ORFNames=Tc00.1047053510823.30 {ECO:0000313|EMBL:EAN89091.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89091.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89091.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89091.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89091.1}.
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DR EMBL; AAHK01000786; EAN89091.1; -; Genomic_DNA.
DR RefSeq; XP_810942.1; XM_805849.1.
DR AlphaFoldDB; Q4D995; -.
DR STRING; 353153.Q4D995; -.
DR PaxDb; 353153-Q4D995; -.
DR EnsemblProtists; EAN89091; EAN89091; Tc00.1047053510823.30.
DR GeneID; 3541829; -.
DR KEGG; tcr:510823.30; -.
DR eggNOG; KOG1516; Eukaryota.
DR InParanoid; Q4D995; -.
DR OMA; IEEPLCG; -.
DR OrthoDB; 1651930at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR049492; BD-FAE-like_dom.
DR PANTHER; PTHR48081; AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C; 1.
DR PANTHER; PTHR48081:SF34; KYNURENINE FORMAMIDASE; 1.
DR Pfam; PF20434; BD-FAE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 253..395
FT /note="BD-FAE-like"
FT /evidence="ECO:0000259|Pfam:PF20434"
FT REGION 91..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 67378 MW; 656BE30E26DF723A CRC64;
MLQYLVRQVL WTISVSAQLL AAMGLGFKWI SMAIRLLVFA LLILWYFIPH ICAYIMSPNI
IRRVSYRSSK RTRQRNLQIF LQQVKSIPPV RRKENGREVS EDPAEQRSGP DMDAVELLAT
KLNPADGRLM MGLPRRLSSP TRTTEVLDDE KVMKIGSFSD TVAFIQSYYA TASAGEHAAS
NGVPAGEHKN PDWASDAAQE PNSTGDSEDE EDEEDRNNLH NRAALDIYLP IPLDSLFRMM
EQEKKISPRS RLQHKKFPVV ISFNGGAWIV GFYLWNFLLA PLLAARGYVV FCPDYRNFPQ
TDMEGMILDV SDAIGWVINN AGRYGGDPED ITVIGQSAGA HLTMMSILSQ AQLSARAASG
GTAPSDMAYN VPRYNPRVSI RQYIGLSGIY NIRGLVKHFD RRGLYRNVLY QIAGGRSNLP
RYSLNSYFDE RRCGDTGEVL PENIFDFLPQ RMYFIHGDAD CSAPFSESAN LAFFMRNAQR
ARLAEQYTNG GQTMGICLAP PVDIKYILVP GATHTDAIIE ECLAARESHV VDFLCYYSTD
NEERDKCLNN SNGFRDVNNK RDEDDGQLDP SRHPDGVLPS PAPHSERPML IRLSSYVCPF
//
