ID Q4DA15_TRYCC Unreviewed; 470 AA.
AC Q4DA15;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=NADH-dependent fumarate reductase, putative {ECO:0000313|EMBL:EAN89370.1};
GN ORFNames=Tc00.1047053510213.110 {ECO:0000313|EMBL:EAN89370.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89370.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89370.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89370.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89370.1}.
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DR EMBL; AAHK01000755; EAN89370.1; -; Genomic_DNA.
DR RefSeq; XP_811221.1; XM_806128.1.
DR AlphaFoldDB; Q4DA15; -.
DR SMR; Q4DA15; -.
DR STRING; 353153.Q4DA15; -.
DR PaxDb; 353153-Q4DA15; -.
DR EnsemblProtists; EAN89370; EAN89370; Tc00.1047053510213.110.
DR GeneID; 3542146; -.
DR KEGG; tcr:510213.110; -.
DR eggNOG; KOG0534; Eukaryota.
DR eggNOG; KOG2404; Eukaryota.
DR InParanoid; Q4DA15; -.
DR OrthoDB; 169293at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd06183; cyt_b5_reduct_like; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 8..208
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 350..446
FT /note="Oxidoreductase FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF00175"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN89370.1"
SQ SEQUENCE 470 AA; 51514 MW; E68DD7F0B0F2B8C3 CRC64;
DPKDPANPTK YLGPEALRGS GGVLLNKKGE RFVNELDLRS VVSNAIIEQG DEYPDAGGSK
FAFCVLNDAA VKLFGVNSHG FYWKRLGLFV KADTVEKLAA LIGCPVENVR NTLGDYEQLS
KENRQCPKTR KVVYPCVVGP QGPFYVAFVT PSIHYTMGGC LISPSAEMQL EENTTSPFGH
RRPIFGLFGA GEVTGGVHGG NRLGGNSLLE CVVFGRIAGD RAATILQNND TYLWGEKWSQ
LKLRNVMEDE NGFMWLHFTF PSSFQVSGLE ALQGVVLRSV SGDKSVEVYT PYTLPDDEGV
VGIALSPWLT GNGVHWLRTL QPGDTVEMKA AERVERNYMN MLKAPHKVVI ATSRGIAPMM
QILRATMERP EKDATIHLIY IADRASSIPY REKLKALAEA SPERFRCTFV LQHPQPGWSG
AVNYLDEIAA SVFPDPAVVI FLCGASEETR SIKSSLLDMG HDVATIATVE
//
