ID   Q4DAB8_TRYCC            Unreviewed;       984 AA.
AC   Q4DAB8;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Roc domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Tc00.1047053511021.30 {ECO:0000313|EMBL:EAN89465.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89465.1, ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN89465.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN89465.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAN89465.1}.
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DR   EMBL; AAHK01000741; EAN89465.1; -; Genomic_DNA.
DR   RefSeq; XP_811316.1; XM_806223.1.
DR   AlphaFoldDB; Q4DAB8; -.
DR   STRING; 353153.Q4DAB8; -.
DR   PaxDb; 353153-Q4DAB8; -.
DR   EnsemblProtists; EAN89465; EAN89465; Tc00.1047053511021.30.
DR   GeneID; 3542271; -.
DR   KEGG; tcr:511021.30; -.
DR   eggNOG; ENOG502RJPN; Eukaryota.
DR   InParanoid; Q4DAB8; -.
DR   OMA; ESYHSHT; -.
DR   OrthoDB; 148126at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR   Pfam; PF08477; Roc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT   REGION          73..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  110972 MW;  AF7240DC1B11FA65 CRC64;
     MSFEGDAALH SFTEGGAELA FHDSQVDALI TKNENCAVFP TLTPNESESL CISQSVPLVD
     GGDLPLSEKI AVGRTAEQEG HNSEERRGPL ISDEEEKAAN PSCMPNKILF GLASVGKILD
     PSSVNATIRR EGPTAGGMRH CSTCPESSLC AQSAEDTAIM GSDENTTAAL RPQVVQEMLQ
     WLGVKRRGDL LSRYLVMGSV AATQHGHGVN DACSLGSKEK HVDPQMRNLL LQEVQRTGSR
     GRFPNKQIFQ RKLVLLGHQE VGKTSLRKCF ESEPYFLKKL PDVKTTTGVE VCSQTICVGE
     DCVQLILSDF AGHEVYHSHT RFLTDRSIFL LVWKISSVGQ DFQSSGISVK EEERLYKWIA
     EVYAKFPRAK MALVATHLDE LRVQGQRSVE RILLRVEKKV TSFMQRIAAT DPTTGKIVTN
     EIVGNFAVSC KTREFIATGG LRRFSVRKLS ALLHFFAEVA RRDCMEDTDF PAAAIPGRHL
     KLLEMLMNEK KRFPEKFFMP LRDFIYSAVQ FGVASDEELL QIARLMYSWN IIYLFNPYCF
     SDNSPIMLRP LWLSRLAAAL FSYAQVIRTP LHLRSLIGRL EYTVSVAEAA DMHLMSKGFL
     RWPLVRVLFR APLFDILGHE PDDLDYTVAV RFLISLSLLY PVLIPCDELA LLEEETPIDI
     EAGQPIVREP KITRYFVPSL SPYFVPDSLR RLAPVLFKRG PKLRFLFNLL PDEAWWRFQF
     RLHSYQQVVV LQEPCGALLA DNKGDDDGGD AFDEYRLLEA DEEHNRWNDA MWLSGDCCRV
     FLYREGLQVI RVFSAETKPH AAESVLEDIE RTISSLLGEY RGLQRTVQIE CPEPNCNGWL
     MSSELLTGTR LKCQICKQMI STEDVVAFAA VECVEPRRSH CFSDTLLKEA GELLCFSLNP
     MGCMQFCEYL GLDHTILCGA ISKDSCNTDG DEEVTQTEQN PDYMYALDKV VRAAMLRQLR
     ERVEEEARRR RMLEPAPTAL QVSF
//