ID Q4DAK1_TRYCC Unreviewed; 924 AA.
AC Q4DAK1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 72.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN89555.1};
GN ORFNames=Tc00.1047053511449.70 {ECO:0000313|EMBL:EAN89555.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89555.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89555.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89555.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89555.1}.
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DR EMBL; AAHK01000733; EAN89555.1; -; Genomic_DNA.
DR RefSeq; XP_811406.1; XM_806313.1.
DR AlphaFoldDB; Q4DAK1; -.
DR SMR; Q4DAK1; -.
DR PaxDb; 353153-Q4DAK1; -.
DR EnsemblProtists; EAN89555; EAN89555; Tc00.1047053511449.70.
DR GeneID; 3542368; -.
DR KEGG; tcr:511449.70; -.
DR VEuPathDB; TriTrypDB:TcCLB.511449.70; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DAK1; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 95..441
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 97244 MW; 5F66FF11B0DCC48D CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESERRRPNML RHLFYSAVLL LVLVMMCCNA
VGAAEGPEQS TVSKFEWKDV KDEGGGDLTV ESLGAPGLLK VGSDVFAVAE AKNTGKEGQG
SFTGIVSQLL TETAKKKDNT PVEIMNDANT KTQFLEESIS AGPKKKVDVS RPTTVVKGSD
IYMLVGKYSR NDAQGSGGDW GLLLVEGEVG GEENSKKIDW KNTESLPRGP FGTELESLMG
LFGGGGSGVK MHDDTLVFPV EATKKGDAQK DVKTVSLIIH NSKDAASWKL SKGTSADGCS
DPSVVEWKDK KLIMMTACDD GRRRVYESGD KGESWTEALG TLSRVWGNEQ DGEGGVRSGF
ITATIDGVDN NRNVMLVTLP VYSEEADKGN EEKSELHLWL TDNTHIVDIG SVSDDDAAAS
SLLYKSGESG TNNDELIALY EKTGKGESYS LWSVVLTEQL QRVKEVVATW KKVDQTVSKL
CPSGSTEKSA STDNACSAVI PTDGLVGFLS GNFSGNTWRD EYLGVSATVN DDGGDKATLH
AGGVKFRGAW AEWPVGSQGE NQLYHFANYN FTLVATVSID KVPEEGSPIP LMGVRLNDEK
KTKLMELSYD SGNKWQVLSG DKTFKELKSA LEPEKTHQVV LVVRNSTQGS AYVDGKQVGG
DEACALENMD SRAVSHFYIG GGGGSAGGAG RQEEEMSVTV TNVLLYNRPL SAAEIGALNP
NKPSISPVVP ENGQGTQSHS SSAGQSPLRP KLLNGNEGAG GGRASPSEPS TVTTSLGKEQ
SEIQPPSVIS SGGSKHVDVA SSSDGDPTVG AEAGGAMQGD TPPQTPVDTP DTAGANAPTA
TDTAQVGPTA TTGVGAISGA NVETAEGRDG QEELHARDGE VKGAALSSSL GNVSQGNNSD
AGTVCGSGLL PLLLLLGLWV FAAL
//