GenomeNet

Database: UniProt
Entry: Q4DBL7_TRYCC
LinkDB: Q4DBL7_TRYCC
Original site: Q4DBL7_TRYCC 
ID   Q4DBL7_TRYCC            Unreviewed;      3011 AA.
AC   Q4DBL7;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAN89926.1};
GN   ORFNames=Tc00.1047053509461.90 {ECO:0000313|EMBL:EAN89926.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma;
OC   Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN89926.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN89926.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J.,
RA   Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T.,
RA   Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D.,
RA   Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H.,
RA   Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R.,
RA   McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S.,
RA   Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U.,
RA   Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L.,
RA   Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E.,
RA   Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N.,
RA   Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAN89926.1}.
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DR   EMBL; AAHK01000691; EAN89926.1; -; Genomic_DNA.
DR   RefSeq; XP_811777.1; XM_806684.1.
DR   ProteinModelPortal; Q4DBL7; -.
DR   STRING; 353153.XP_811777.1; -.
DR   PaxDb; Q4DBL7; -.
DR   EnsemblProtists; EAN89926; EAN89926; Tc00.1047053509461.90.
DR   GeneDB; TcCLB.509461.90:pep; -.
DR   GeneID; 3542807; -.
DR   KEGG; tcr:509461.90; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   KO; K04958; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002296};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2567   2597       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2643   2668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2688   2710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2768   2790       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    200       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN      663    874       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN     2150   2243       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   DOMAIN     2643   2796       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     2392   2412       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3011 AA;  337362 MW;  F092B057B31A8086 CRC64;
     MDRKQRIIKY GSLVHFSCEE GYIAASGLEA EDLFIREKND TDIDEEPLPL LGFETSVFRI
     EAPASSLAAK AQEAVADRFS NNNTLLMEHF SNINTAPELM YGKPFLLLHS VSQMCVAVFP
     SKPSKSDPNC VRLVLVKAGE VESDFCEFVV TPRYKIHDDG DPVCRGDEVL LRLAAFPIFV
     HVTGRKHPGL NTWGMPSEED GCDSSINAFE KGLAAGRMVD DLRSEVNGSE ERAVGFVVQR
     YDIGRDQANY QRALYHIARP YVPSGVPVLL YHRERESFLT TSLTSQPRQQ KESEENKKTM
     EANVVSGGDN GISGGALLTN KESSFVEGVF VSRSATQLEG SGISTLDTPD ANDNTDGDVD
     HTGTPFPLLM KDETSTGCVS NEGTALNDFW RSCTALWILE NENPTIGGAV RMRSVKYRLR
     QACSNMYLAV AGSGVDAFFE GNGESDFSET VDGMGAAALE EGGDAGSNSS RNQLRAASLC
     MIPPPRTAKD SQRTLFTLTP MFFTECNFLI ENDCLTLQNV LTGMYVCTQE ARDRLFLQWQ
     PSVSDTITVR SSRQEIVQDV MFLRSHCERL CRYRDAFQAL ARLKNSRHPS FHRDGGGLEP
     YPGKHESSDS CEENLTPTRA AFVQGGALST DFAVSSLGRQ TRTTETPYAA ILPVIYASQS
     SLEELIRFCS LARVHDALRL DGIPIVRRQR MIFELNIHRL VMDVILTPFS LLQSEETDGM
     GDKTMSGMLP WGCSPRLPPL PLMGGFFCMG VALDDAHSEV HLVCRLAFRF LRQMVRKAKM
     LKKWLVEFIP YFLELGGYRF RVSDTMTELF SENNSVPRPV VESVADHFIG SLRRGRSAGH
     LNLLSSMCTV GFSGIFERQA MVCQKLLVEN SELLSRFVLN QNGEWAVVVN EGEAPVECGA
     LFELTRPQNS QQQLGSDAKY ARFLQSEIQL LGCLCFDGCP SMCCAEVGRV FPPEVLLRAI
     QTFVWTGAEV MGSPSPLDLL RGHILRLAVQ CYIMPRIDDP AVQLRASTVL FGSSSLRLRE
     ETHLPISGKP DDDLISSVKA AALNIIRANP HFVQSDMSRS VLLRVSINAW LRLVKAHQIS
     VQEMCDLIPP LLGLLDGTKD IVDDNASRVA AHTLTRLEVS EASVQVMETR EMICNTLLQL
     LETVSNRVAD NIILLLYDAF VKGGSFPRRK MFVLLDFDEE PVLDAKYDLH VWPSEGQALL
     CEKGTGLLHR VRGKYQSVDI TDEAQEMDSN RIDSKEVVEL LGRVCKSIML RFRVKELVPL
     LMDLTRYESQ QLTARATELL IRLCVVKRTV AHRVLQVHTL PSSEVVRSFD HLYTVAVNTL
     TLERRGCFDE AIAFALSNIE EPEGTHDDSV PSEELEEEYL IEDDGSDDEA GGDDGGAGAD
     QAGKEAHGGR HLWGKTAGAV RVLAYHNAVR RRRRSVGLSE NSELPLRLIV RMELVCHWGI
     HIPLMRMHAS IDPNSRAFFQ WMRFFYLFTF VRGNARKLLG SIDLFMRSLN LKKECTVMCL
     HIIVAIFASV ADPTPYLSNT FLTECVKYLD SEVSTRHADV DFLSRLSNYV FSNPAVGGVP
     RRRMMQLLRD YNILRCLPRP GGVQVSPVRC DFIASMVELL CHICNCPTSA LAMGQRALPM
     QDIFAIILEY GSLYSPLHRK SYHQRDELER KQFQLVGTYL RALVLLYITA EREEGGQGKE
     MIKLEWMANR EWWAVVEMLT RQLHGITELI LTNKGKVVNR GIRVIQRYRH VWLMSLPVAL
     LTFFSACFSE AGFYRYQDSV GVTFAVMCSS LMEFSSNLIS NSDALELSVQ EAVNYRRLLG
     LLHMQTANIV GLETLSSQLE IVRDQILHWL LQRERLSKAE RQGQGGGWEE RARSSDFDEY
     SSPHDTLAIG EGVSQRIQDS LGDSFSARLF LSSGVSRCRE LEATRSALRT FVKSDVLIPI
     EDSLEIGEAA NVVNALLCRS SALSGVRGFV WSALDGMRKR YFSPMALVGL LNLFYNALYA
     SFYVKESPPL QAAEGAGKNS TEREDTWNLL QLTFTDLGMS NVVASLSVKD DDVITYSSIR
     LSVMLLEGGN TRAQYALLKD FGAHQVRFFH NIRELLQKSL QWVRQINLQQ QLVILECGGT
     PVGSNSTLFT SALFAAVLKS SSYRKKSERN GGKEKHILGW DRVEGCMRLR LLHALFRMLQ
     LFCEGHNLGM QNYIRFQHDN MHSVNIVHEV LLLLAELSGM THGATVDVIR GGFELLTELC
     QGPCHENQTA LLSYDVCVTM CGLLDVLSKL EIIGTRTAPE NNSRNMNTEM GITNTTNTNG
     TRLTESFMNG VVSQRGLKLT RKAVDCLRVS LTTFLLSLIE GCRSPETFRR VLAQIPIEII
     EHQLSIATPE MCDRILEDET LEDDPTVAAL FNWLIFLHIV RPFADGLYLQ HIDELLRRTT
     RLRERLGRIE IRRDDGLLEK VFFCIPSICR GLSQNIKDDV LWSVNRTSRA TKLGDFLHQS
     DNLIFEVERA HDFQRWVARW TRFTLTTTDT AVEKENETDT EGVMEEKKVR FYSLKKCWNR
     FMAPFIFSSQ LSYYEYASIL IAVLINIGLI SVEGAKWDWA TVQVSELAIT CLCVLQFVLS
     CVTLCMDAVV FFPACLYKEY RRKEHMRLGI AKLNATMREV FDGLTKGEVV YHFLTRFTIQ
     FRLFLVVTAA LSLLVSRYFA AAHLLFVIYK VPTLCTFINA ITQNGKQLLL TAFLGVVVLY
     LFAIVGYLLF PRQFDSSDGP ENGNCVNLFR CFLFILWQGL RQGGGVGDIM QEESWSSSTL
     FPRVSYDLVF FALVNVVFLN IMFGLIIDTF GELRDAKREK ELDMKSTCFV CGLEADEFER
     AHVGGFRAHV VHEHNMWMYF YFMHYLRRKD PNDFTGQESY VDERIRRGDL GFFPEEDSLS
     LGNGGREEDA AAGAQKDVSG MDEEGCATRP GREKAPAAGS GAANGQEVAL TLKELAGVKE
     ALSAFVRDVS ADAQKVKSLL QQLEIMSRGA HVMSLGGGTA NDPGSTSGTR LSRGEGSKSS
     LRRSIGEGSK N
//
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