ID Q4DE17_TRYCC Unreviewed; 952 AA.
AC Q4DE17;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=Tc00.1047053509663.37 {ECO:0000313|EMBL:EAN90770.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN90770.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN90770.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN90770.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN90770.1}.
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DR EMBL; AAHK01000590; EAN90770.1; -; Genomic_DNA.
DR RefSeq; XP_812621.1; XM_807528.1.
DR AlphaFoldDB; Q4DE17; -.
DR SMR; Q4DE17; -.
DR STRING; 353153.Q4DE17; -.
DR PaxDb; 353153-Q4DE17; -.
DR EnsemblProtists; EAN90770; EAN90770; Tc00.1047053509663.37.
DR GeneID; 3543858; -.
DR KEGG; tcr:509663.37; -.
DR eggNOG; KOG1967; Eukaryota.
DR InParanoid; Q4DE17; -.
DR OMA; TRAMNAY; -.
DR OrthoDB; 124738at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 42..300
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
SQ SEQUENCE 952 AA; 106126 MW; 48F522469DE5BFFC CRC64;
MPSMSGEKVD NIIERAISMG LNCDEETFEK LRQVPLLQLC RMMSRYLTDE KHIIEALFVL
SLATTRRKTL LDEEAVVVLK FFLEKLSSLQ TIETSVECIT RVIEYLSSQR PCSKIVFTEL
ANGFLPNVRL QALPTRVRRS GFKILKYMVS EATVSWLTTP VLCLLLEAMD EEGEPELVLH
MFELYYFLSF FVDKNNIVPL KEQYFDSISS YFPVVFSRPP GCSVTREELK RSLTRCMTCP
LYLDPCVSFT LSRLSSPSSF VKQESIAVLL ELFSPESAHD MNDLSPHILP VVSHVRNEVI
KGVSLGFSEG DSYIRDCMNL LSFIGKRSHG VLSPVIASWI EPAISGALTS LNSGSATCSA
YATMFYHLAR SDASCGTSLL SHFLPLLLMN LNEIDGGKEN AFIILSAVFT GILDLCTTDE
VHHGLSSTLD DVKRSLELSS PELFRLVETL LLALKMAESS SKIIMCELLS SLLSLDVYLH
PWMPVESVQL SYENLLLISL QGNEEIHIKV ARCISRIGHL EGNGLNNAIV HLLEKETKFN
ATGIITLFNA LLMSSVPVAL LAMELLLNPL RSLVESRLSE SDVFSLCRRA LSENADFSEE
DILHLLQIVV LKNLPASLEF LCELLVRISL CSIEKTVLQM VDGKRWSILV IALLSSCDSD
VLHVSETLEH WVTEMLNAVQ EEEFRRVTIQ GVSAICAHAP NALEGFLTRS RGLDPELQLA
VHAAAARGLI KAGLAMDGEV KGIILRLLDA ICSGVDIDEV LTATFFSPSL GSNKCVTLLV
PFIQAVRTSN IPMPDKVLNV ILQLLGKEAI GLEFDWSSIL EVCENLARQK PSEGHVIGIL
QLLDCVLLRI DSKVFFMKRI LTNDGALFQM LLSAVRSSDL QARCTALRLL SEVAMFAVQL
TATNNEDELN YKRIIAREKE GVLHLTQILL ADHKRVVRRA AAQCRHQWYK LR
//
