ID Q4DEI6_TRYCC Unreviewed; 936 AA.
AC Q4DEI6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 72.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN90943.1};
GN ORFNames=Tc00.1047053511643.110 {ECO:0000313|EMBL:EAN90943.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN90943.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN90943.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN90943.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN90943.1}.
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DR EMBL; AAHK01000571; EAN90943.1; -; Genomic_DNA.
DR RefSeq; XP_812794.1; XM_807701.1.
DR AlphaFoldDB; Q4DEI6; -.
DR SMR; Q4DEI6; -.
DR PaxDb; 353153-Q4DEI6; -.
DR EnsemblProtists; EAN90943; EAN90943; Tc00.1047053511643.110.
DR GeneID; 3544071; -.
DR KEGG; tcr:511643.110; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DEI6; -.
DR OrthoDB; 132268at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 152..503
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 70..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 100232 MW; 386756EFA505B7D0 CRC64;
MMMPVTLDGS RCSLFHSFSF FLSYSHTKER SYKRALIAIV KFEGTESTNS THTAHTHIYM
HSRVAAVKAP RTRNRRRVTV SSGRRREGRE SEPQRPNMSR HLFHFVLLLL VVMAFGGSGT
VTADEEQEPA DPTFEWKGIT EGDDVTVDLL GAPSLLKVGN EVFAVAEAQC KKNGDVSFTG
VASQPLTTKT TNTPEEVLKE TKDTQVLEED GSERQNKRID VSRPTTVVEG SGIYMLVGKY
IPATVGGAEC KATSEKIKSG ILLVKGEVVV GEGGNKIHWN DTDGVPCTLG DQQNSLKRLT
GGGGSGVKMN DGTFLFPVEA VKKKENDDAD EDGKTVSLII SSSQDFTNWK LSKGMSADGC
GDPSVVEWKD AKLMMMTACA DGRRRVYEIG DKGESWTEAL GTLSRVWGNN KKGVSGVRSG
FITAKIDGVK DNRNAMLVTM PVYAEEVNKK GKLHLWLTDN THIVDIGPVS GDDHDAAASS
LLYKSGKSGT DDKKEDELIA LYEKKKGGDE GKPSPGLVSV LLTEQLERVK KVLATWKEVD
DRVSLLCTSL IAQEDRSTDN VCGAVKITDG LVGFLSGNFS DGTWRDEYLG VNATAKNGAA
AATGPSDGAK FTGRGAGAEW PVGKQGQNQL YHFANYKFTL VATVSIHNVP EGTIPLMGVR
AGSKGEKKLI ELSYDSEKKW QVLCGDGNPT ELSSILGTET PHHVVILLRN GTQCTAYVDG
QRVGNAQCEL GSGESNEISH FYIGGDGGSA DDQESRGDVS VTVTNVLLYN RPWDDTEIGA
FNPNKANVPV EVDRPVEGEA IQSSSGGRPE EQRQSLVSSG AGVVSAPTVS SATISSVGEE
SVMQVVSEES SDGHKNVGGA SFSDGDPRVE TREEGTDGQE KEEIQAQNGD VRAAALSSSL
GNVSQGNNSD AGTTRESGLL PSLLLLLLGL WGFAAL
//
