ID Q4DFD2_TRYCC Unreviewed; 1083 AA.
AC Q4DFD2;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Ubiquitin hydrolase, putative {ECO:0000313|EMBL:EAN91240.1};
GN ORFNames=Tc00.1047053507017.120 {ECO:0000313|EMBL:EAN91240.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN91240.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN91240.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN91240.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN91240.1}.
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DR EMBL; AAHK01000542; EAN91240.1; -; Genomic_DNA.
DR RefSeq; XP_813091.1; XM_807998.1.
DR AlphaFoldDB; Q4DFD2; -.
DR STRING; 353153.Q4DFD2; -.
DR PaxDb; 353153-Q4DFD2; -.
DR EnsemblProtists; EAN91240; EAN91240; Tc00.1047053507017.120.
DR GeneID; 3544426; -.
DR KEGG; tcr:507017.120; -.
DR eggNOG; KOG1275; Eukaryota.
DR InParanoid; Q4DFD2; -.
DR OMA; PECWITT; -.
DR OrthoDB; 9810at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06143; PAN2_exo; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR028881; PAN2_UCH_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15728; DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR PANTHER; PTHR15728:SF0; PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF13423; UCH_1; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000313|EMBL:EAN91240.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 834..1017
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 1083 AA; 120873 MW; 4487ABAD9ABB6B69 CRC64;
MNVHWKPRGG AQASVGIINA VEFDPDVELL WVSDSFGRLM SFTTQSQTNT LTWTTYSSFL
ASTRPISGIF FLPLGGEKIV TVADHNVIRG YKRGGALFMC RSLPPQSQDY IELFQAHGET
GVVSFTGNAG LTRFSIGNEG NDGVVTVPLG ESKVVALHQT EKWVVTGSIS GSIVVRDSSD
LQLVGAVPSS RRRVLAMDAY DNTVVAAMVE RSMTSSVRVY DLRKLSEPVI TIGGIPSDSV
SQLRRYRDSF GISADRAFVL TPCGFHILQM DQTSPVFNSN GMVGDFCTSV SISPNGMCAA
IGNDKGYFIA LAHPATREDY VMSRFEQPRR PVNPVFTQSW AEKKEGDTFA FFDESVPPAE
LASNWPPDNY MILSVPAPTR CLSVESRTIL QNRWGFLRAD SYLPDPKDKM ALNLPDPFPF
NLELGDDPAA VQGLLQEMKK NQKRRYFEFR DVAAGEYAPL EPASHVCYSS HHRFDWENYN
AIPQEVVGLD NSFPECWITT LLQSLYLCHL PECPVRKVLL HHLCTREYCV ACETSFIFAN
MMMTSASGLN PIVQVANLIR TMYKVPATAS LFEPVKSRDE AIKRMHTAQL TLLEALHRGL
QDEKAYPFMD HKPPCNDFEH SIAYLFGTEF SSGGRVHLEP QFYWDVPSSA LKVNEGLQHL
LKQIESYRDQ VQIKRLPPII VLRLNPEGGT LKPPRCLHIS REAQEDSNYV LCSNIIHLSD
DADDPGSFVS HQRILDDRFS LVNDYRVTAP MEEEELEESM PAFHSHRAVV AYYALDKLTA
PPYSLHDGNR PPNMFEVLGP LLVNDVLAKP LQRDPSAQRF KSPLASFYEI KPNDLIAIDA
EYVVLSWNSR CIDAGMEVKL SHKTHMALAR LSCVLSSAPG DERTIVDDYV HTPEVIEDYV
TQYSGIHPGD LDPLKSTKCL TSRKATYLKL RALVDRGVIF VGHGLYQDFR VCNIAVPPEQ
IIDTLMMFHK PGGRYLSLRF LAYHVLGERV QEDEHDSVED ARTSLRLYRK YQQLVSEGTF
DAVLDKLLAT GAETSWYVPE GRDAFGASPA LFASIPGSLL FPESPSTLVP AEAAKDDEFP
SAS
//
