ID Q4DGT8_TRYCC Unreviewed; 596 AA.
AC Q4DGT8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Aminopeptidase P1, putative {ECO:0000313|EMBL:EAN91746.1};
DE EC=3.4.11.9 {ECO:0000313|EMBL:EAN91746.1};
GN ORFNames=Tc00.1047053507081.110 {ECO:0000313|EMBL:EAN91746.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN91746.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN91746.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN91746.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN91746.1}.
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DR EMBL; AAHK01000496; EAN91746.1; -; Genomic_DNA.
DR RefSeq; XP_813597.1; XM_808504.1.
DR AlphaFoldDB; Q4DGT8; -.
DR SMR; Q4DGT8; -.
DR STRING; 353153.Q4DGT8; -.
DR MEROPS; M24.009; -.
DR PaxDb; 353153-Q4DGT8; -.
DR EnsemblProtists; EAN91746; EAN91746; Tc00.1047053507081.110.
DR GeneID; 3544999; -.
DR KEGG; tcr:507081.110; -.
DR eggNOG; KOG2413; Eukaryota.
DR InParanoid; Q4DGT8; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EAN91746.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAN91746.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:EAN91746.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 12..140
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 304..521
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 532..595
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 596 AA; 66546 MW; 39CFE6AA37912B27 CRC64;
MMSTASKILA ILREAMRKRS LSALIIPSSD PHNSEYVKDE YKCRAYITNF KGSAGTCLIT
MNEAYLWTDG RYWLEASQSL YPEWTLMKDG HPDVPKLENW IQLNLGSDVL VGMNNHLSTV
AEWERRRKMF NLVPVPEMVQ PLMPLVENPV SNLYARPEEF CGMRCGEKAA ALIEEMEQQK
CDALVLSALD EVAWLTNLRG SDVPFNPVFY AYGVLRRCSP PKVHLFVDAV MSEEQGPSLE
LHPYTALESY LRTIPAGTTF LLDEHQTSQW LFTLLESLGM RIKRVACGPA QKLKAVKNAV
EIEGFRRCHV RDGVALTRYL AWLHDTVAVK GDTSVTEYSA AQRLEDFRRE GEHFVQLSFS
TISSVGPNAA IVHYVAPREG SATIVPDQLY LVDSGAQYLD GTTDVTRTVC FREPGDKERE
AYTLVLKGNL ALHSAVWPTG TSGHSLDVLA RAALWKCGLN YAHGTGHGVG SFLNVHEGPQ
GIGLRPTPTE ATLAAGMVMS NEPGYYKDGE FGIRIENLEL VVDVATKHSK KGFLTFDTLT
MVPLCHELID VSALTEAERQ QVNAYHQTVR ETLLPHLRRC NDSCAIAYLE HHTRTL
//
