ID Q4DJ46_TRYCC Unreviewed; 754 AA.
AC Q4DJ46;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=PDEase domain-containing protein {ECO:0000259|PROSITE:PS51845};
GN ORFNames=Tc00.1047053511755.100 {ECO:0000313|EMBL:EAN92553.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92553.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92553.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92553.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92553.1}.
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DR EMBL; AAHK01000426; EAN92553.1; -; Genomic_DNA.
DR RefSeq; XP_814404.1; XM_809311.1.
DR AlphaFoldDB; Q4DJ46; -.
DR SMR; Q4DJ46; -.
DR STRING; 353153.Q4DJ46; -.
DR PaxDb; 353153-Q4DJ46; -.
DR EnsemblProtists; EAN92553; EAN92553; Tc00.1047053511755.100.
DR GeneID; 3545925; -.
DR KEGG; tcr:511755.100; -.
DR eggNOG; KOG3689; Eukaryota.
DR InParanoid; Q4DJ46; -.
DR OrthoDB; 152874at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR11347:SF230; HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A; 1.
DR Pfam; PF00233; PDEase_I; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 293..564
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT REGION 194..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 83592 MW; D5F56BEAFABEBB3B CRC64;
MKAPAAHVPV KRIADSRPNE RLMALFIAQL RKRLAESTSL DEFNNWMNEQ YQALEASLLE
PQSLRPLVDA VGEAVLTPTS QETLTECGDE YIEHGVYWAP ETQGNPCTTF SSTTESFRVN
TPASIGKLNR ASPRAANAAE TNTQNLLQHE MNRLLLSPRS TGPGEDVKTE KEALSVLQLS
SVWAPSIFHR GIAKPLGRGK PYRGSETNPL GFGDSHGSEN QSYSILPDSI HGASTVSHRT
GAPPLRNGVS ILDIGSNGDF GEGMPAFSLD GRLTNQGPIF SRSSSRHSPV FRPIDQVQEA
LRSVGVPFLG DVNSSNVDIL HYRQCYGPKA YVYTCLNVLL RYNFSVRFGF NVRRLYCFYN
TAVNYIFPGN PFHNAYHASD IVLAANQFLS EPHVAENFSD EELFSFLFAS TVMKLGHVGM
TNAFLIKIHH PYAALYGFFS PQQSVSLALG LTLLDTPECC FPTVASSQES DHDSTPSVWT
HEKGVELYEM TAQLIISTDE RRHQVLLNQL QQILREGAGN VVRESHLMII LQNVLHAADF
CYVFRLSSVY RIAAACAVAE VYQQNQTRIW LTERGLRQWP WNGPHAATAG EKRAKESNNN
ILGGFFSCEG SFYGMGECRE PEKVPSMYSD LTEGLTPSNP SLTPSVGHIG EASGFSPLHH
AKVLQTAVLE TVFLPFIFTL SPFVPDYWLT NAQSNLVWLG EFSADAFEAD VMGLLRHPET
GGLRLRSIGA NGFERRVLRR IVDPLFQQHT EETK
//
