ID Q4DJE0_TRYCC Unreviewed; 923 AA.
AC Q4DJE0;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN92641.1};
GN ORFNames=Tc00.1047053508789.120 {ECO:0000313|EMBL:EAN92641.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92641.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92641.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92641.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92641.1}.
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DR EMBL; AAHK01000417; EAN92641.1; -; Genomic_DNA.
DR RefSeq; XP_814492.1; XM_809399.1.
DR AlphaFoldDB; Q4DJE0; -.
DR SMR; Q4DJE0; -.
DR PaxDb; 353153-Q4DJE0; -.
DR EnsemblProtists; EAN92641; EAN92641; Tc00.1047053508789.120.
DR GeneID; 3546035; -.
DR KEGG; tcr:508789.120; -.
DR VEuPathDB; TriTrypDB:TcCLB.508789.120; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DJE0; -.
DR OrthoDB; 132268at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 96..447
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 97509 MW; 62EEBFC5269E35CC CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGG ESERQRPNMS RRVFTFAVLL LFLLVMMCCA
CEAAHAENSA SGTDPKFEWK DANGGVGDVT VKSLGVPGLL KVGSDVFAVA EAQCKERETI
FTGIATQLVT TAKANEPKEV LKDAKDKTQF LEEGTTAIKK KVDVSRPTTV VKENEIYLLA
GKYSRTAAAD DGESGAGDWG LLLMRGNVSV EGGNRKLQWN ENQRLVRALF EGEQDSLMQL
VAGGGSGIQT EDGTLVFPVE ATKKNSGQSE VVGGKTVLLL MYSSDASNWK LSKGMSADGC
SDPCVVEWKD KKLMMMAACG DGRRRVYESV DMGESWTEAL GTLSRVWGSP KGANVKAVGS
GFVTATVGNG DDDKRRVMLV TLPVPPTERE EEEKEKGELH LWLTDNTHIV DIGSVSVEGE
DKVTASSLLY KGGETDGNNE ELIALYEKDR SGEDTSSNSL WSALLTEQLK RVKDVLATWK
KVDERVSKLC PTSSAAESTS TGTACTSVVT DGLVGFLSGN FSENTWRDEY LGVNATVKSG
VGAAGTTDGV KFRGAGAEWP VGKQGRNQLY HFANYNFTLV ATVSIDKEST EGNIPLMGAK
MNDAENPVLL GLSYNNKEKK WTLLCGDGKN TEQNRIEGKE KTHQVAIVLR NGTQGSAYVD
GKRVGEPCQL EGKEDKKISH FYIGGDGSNK GSQEGVSVTV TNVLLYNRPL DDSEITALNA
IKVPITPPKD QNAQEIVLPS GGTPHAGQEP LNGGKGADGG SASPSASIAS TSVPVGQTVQ
QLASETFPDG NADVDVSPSS SGNPTVGEGS ADTIQGDGPH TPSVGNTAAA ADTKVLTAKG
EGHDGPALTR DVSVSSGADG ETAGGTDGQE GIHPQNGEVK SAALSSSLGN LSQGNNSDAG
AVRERRALPL LLLLLGLWGF AAV
//
