ID Q4DJQ6_TRYCC Unreviewed; 653 AA.
AC Q4DJQ6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Histone deacetylase, putative {ECO:0000313|EMBL:EAN92767.1};
GN ORFNames=Tc00.1047053509395.120 {ECO:0000313|EMBL:EAN92767.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92767.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92767.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92767.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92767.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000404; EAN92767.1; -; Genomic_DNA.
DR RefSeq; XP_814618.1; XM_809525.1.
DR AlphaFoldDB; Q4DJQ6; -.
DR SMR; Q4DJQ6; -.
DR STRING; 353153.Q4DJQ6; -.
DR PaxDb; 353153-Q4DJQ6; -.
DR EnsemblProtists; EAN92767; EAN92767; Tc00.1047053509395.120.
DR GeneID; 3546197; -.
DR KEGG; tcr:509395.120; -.
DR eggNOG; KOG1343; Eukaryota.
DR InParanoid; Q4DJQ6; -.
DR OMA; NIPWPTH; -.
DR OrthoDB; 124800at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF7; DEACETYLASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 2.
DR SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 127..306
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 490..612
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 77..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 71265 MW; 892A9610CA09DCA1 CRC64;
MPKRSRAKKQ VGRDTRVKTE QVNGASEAVA TICKVGLETY IRNWMSEADG ARPPPPSSLP
SLTSFPTILD VMMGMSSPST PEEGAMNATG PDAKQKDGRI GRSAEGTGVV YDDVMLQHES
TDPTDYERPG RLKRTLEHLR AIGLLQCCRR ISRHVARTKE LRLVHSIAHI DSVDQLEVAA
LLRHPETSYS VGQDLYANTS TSRAARMAVG CVIAAALSVV RGEVMNAFAL VRPPGHHASV
NEASGFCFFN NVAVAVRVAQ QELRQRGISA PRALVFDWDV HHCDGTESIF YEDPSVVVVS
IHQHGTGRGH VLRKAPTVFT DTIDLDALAA LMEETTGEEA ASNGDNGHNA SVGGDDWHQH
QTKEEEEEEE EEEAENAEKV QRQNPQLSPE EEGDGRKRAA RRKPVDYVKL AADLEEDDEA
IARMFGISPE DLKKSSSSFS MSKSSDGGGG GSSGSRSSSS HFYSAHLVQK NLPGDTEGLS
LDEDIDNDKD GKFYPGTGHV ERVGGDTRAE ARGKNINIPW PTLGMGDLEY LQVFLDIVAP
VVREYEPHIV FLSCGFDSAA GDLLGSMCVS PSGYYLLTKA VSALCPHLVV ALEGGYNLSN
VARCSEAVMR ALLESSGTAP LPRSRMLWCQ TEELVKRVRQ RHEGYWRCFS HPE
//
